右冠状动脉阻塞时交感神经对房室传导调节功能的实验研究  

Experimental study of sympathetic nerve on atrioventricular conduction modulation in acute inferior myocardial infarction.

作　　者：董滨[1] 曹茂荣[1] 吕芙蓉[1] 文娜[1] 蔡航[1] 

机构地区：[1]武警黑龙江总队医院心内科,哈尔滨150056

出　　处：《中国综合临床》2008年第9期891-893,共3页Clinical Medicine of China

摘　　要：目的 研究右冠状动脉阻塞时交感神经对房室传导调节功能的影响。方法 在去自主传出神经的动物上，结扎右冠状动脉造成急性下壁心肌梗死（AIMI）的动物模型，通过模板匹配的方法检测His束的A、H、V波，自动检测两心房波（AA）间期，心房波与His波（AH）间期，并刺激双侧交感神经。结果 正常动物刺激交感神经使得AH间期在未起搏与起搏时减少（14±5）％和（23±7）％；而心肌梗死时，刺激交感神经使AH间期在未起搏与起搏时减少（7±5）％和（12±2）％。后者只有前者减少幅度的50％和48％（P〈0．05）。结论 在AIMI时，交感神经对心脏传导调节功能减弱，这种减弱可能参与AIMI伴房室传导阻滞发生的机制。Objective To study atrioventricular conduction during right coronary artery infarction and its correlation with sympathetic nerve. Method AIMI model by ligating the right coronary artery of denervated autonomic nervous cats was used. The A, H and V-wave were measured from the His electrode by template matching. The AA, AH, HV intervals with and without sympathetic nerve stimulation were measured respectively. Results The decreased percentage of AH intervals was （ 7 ±5 ） % vs. （ 14 ± 5 ） % （ without pacing） and （ 12 ± 2 ） % vs. （23 ± 7 ） % （ with pacing） respectively in ischemia and normal after sympathetic nerve stimulation, and the decreasing amplitude were 50% and 48% respectively. Conclusion The regulating function of sympathetic nerve on atrioventricular conduction decreased after ischemia related to the right coronary artery. This decrease may be one of the mechanisms that lead to atrioventricular block after acute inferior myocardial infarction.

关 键 词：心肌梗死 交感神经系统 右冠状动脉 房室结 

分 类 号：R542.22[医药卫生—心血管疾病]