藏边大黄对高原急性脑梗死患者的疗效及其血清TNF-α、IL-1β和IL-6含量的影响  

Effect of Rheum emodi Wall on express level of TNF-α、IL-1β and IL-6 on acute ischemic stroke at high altitude

作　　者：刘志勤[1] 朱爱琴[1] 于梅花[1] 

机构地区：[1]青海省人民医院药剂科,青海西宁810007

出　　处：《中成药》2008年第8期1100-1102,共3页Chinese Traditional Patent Medicine

摘　　要：目的:观察唐古特藏边大黄对高原急性脑梗死的临床疗效。方法:采用随机单盲对照法将患者分为治疗组和对照组。治疗组34例,给予唐古特藏边大黄水煎液口服;对照组31例,不服用唐古特大黄水煎液,疗程为4周,观察脑梗死疗效。同期采用放射免疫法,检测2组白介素(IL-1β和IL-6)和肿瘤坏死因子(TNF-α)的水平。结果:治疗组总有效率为88.24%,对照组总有效率为70.97%,治疗组治疗后血清TNF-α、IL-1β和IL-6指标较治疗前明显改善,有显著性差异(P<0.01),而对照组治疗前后观测项目均无显著性差异(P>0.05)。结论:藏边大黄通过下调脑缺血再灌注后IL-1β、IL-6和TNF-α的表达,从而使高原急性脑梗死患者神经功能得以恢复。AIM ： To observe the effect of Rheum emodi Wall on expess level of TNF - α, IL - 1β and IL - 6 on acute ischemic stroke（ ACI） at high altitude. METHODS： 65 patients aith ACI at high altitude（2 260 m）were randomly divided into treatment group（34） and control groups（31 ）. both groups received danshen-safflower injection. Meanwhile treatment group took Rheum emodi decoction orally for 4 weeks,while control group doesnt. Serum levels of TNF-α, IL- 1β and IL- 6 were measured by radioimmumoassay. RESULTS： The treatment group showed much higher rates of improvement than control group（ 88.24% ;70.97% ） after weeks. Serum levels of TNF- α ,IL-1β and IL-6 decreased significantly in patients with ACI at treatment group as compared with those of control group. CONCLUSION： Rheum emodi Wall can improve the nervous function of ACI by reducing TNF-α, IL-1β and IL-6 content in serun.

关 键 词：唐古特藏边大黄 急性脑梗死 白介素 肿瘤坏死因子 高原 

分 类 号：R287[医药卫生—中药学]