羟丙基-β-环糊精包合法提高芒果苷溶解度的研究  

Improvement in the solubility of mangiferin by HP-β-CD inclusion

作　　者：王志萍[1] 邓家刚[1] 王勤[1] 李学坚[1] 韦慧鲜[1] 

机构地区：[1]广西中医学院药学院,广西南宁530001

出　　处：《中成药》2008年第8期1123-1126,共4页Chinese Traditional Patent Medicine

基　　金：广西科学基金项目(桂科基0575084);广西中医学院项目(ZD2005007)

摘　　要：目的:优选出提高芒果苷溶解度的最佳分子包合工艺。方法:用比较法筛选羟丙基-β-环糊精(HP-β-CD)对芒果苷分子包合方法及干燥方法,制成的包合物经红外分光光度法、紫外分光光度法、差示热分析、相溶解度图法及溶解度测定。结果:采用搅拌法和冷冻干燥法,HP-β-CD与芒果苷可形成包合物,主、客分子比为1∶1,包合物中芒果苷的溶解度达35.99 mg/mL,比芒果苷原料溶解度0.111 mg/mL增加300多倍。结论:采用搅拌法和冷冻干燥法可制备芒果苷-HP-β-CD包合物,包合工艺稳定,包合后的芒果苷溶解度显著提高。AIM： To study the optimum condition of hydroxypropyl-β-cyclodextrin inclusion for mangiferin in order to improve the solubility of mangiferin. METHODS ： By comparing the condition of inclusion of mangiferin in hydroxypropyl-β-cyclodextrin obtained,including its drying method, inclusion compound stood the test of infrared spectrophotometry, UV spectrophotometry, differential scanning calorimetry analysis, phase solubility diagran and solubility determination. RESULTS： The paddling process and freeze drying could put in HP-β-CD inclusion compound use the ratio of host/guest molecules was 1 ： 1, the solubility of mangiferin of included complex was 35.99 mg/mL, about 300 times as large as uninclused mangiferin （0.111 mg/mL）. CONCLUSION： Hydroxypropyl-β-cyclodextrin inclused mangiferin compound could be prepared by paddling process and freeze drying. Its solubility of the compound improves significantly and it is stable.

关 键 词：羟丙基-Β-环糊精 包合 芒果苷 溶解度 

分 类 号：R944.27[医药卫生—药剂学]