儿童心肌炎基质金属蛋白酶组织抑制因子-1检测与临床意义  

The measurement and clinic significance of tissue inhibitors of metalloproteinase-1 on children with myocarditis

作　　者：王湛[1] 黄晓忠[2] 潘薇[2] 董晖[2] 张政祥[1] 吴贻全[1] 林曙光[2] 曹源[1] 张紫芬[1] 

机构地区：[1]深圳市罗湖区人民医院心内科,广东省深圳518000 [2]广东省人民医院医学研究中心、广东省心血管病研究所

出　　处：《中国基层医药》2008年第7期1141-1143,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省深圳市科技计划项目（JH20050712844A）

摘　　要：目的评价血液中基质金属蛋白酶组织抑制因子（TIMP）-1与儿童心肌炎的关系，验证临床检测TIMP-1的意义。方法将年龄为1～14岁临床诊断为心肌炎患者9例与相匹配的对照组9例取血标本，测定门冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、甜羟丁酸脱氢酶（HBDH）、肌酸激酶同工酶（CKMB），心肌肌钙蛋白Ⅰ（cTnⅠ）、C反应蛋白及TIMP-1，并行超声心动图等检查。结果超声心动图示心肌炎患儿射血分数显著降低、左心室扩大。儿童心肌炎患者TIMP-1水平较对照组显著降低。心肌炎患儿与对照组心肌酶、心肌肌钙蛋白Ⅰ、C反应蛋白及检测差异均无统计学意义。结论对儿童心肌炎患者来说，血液中的TIMP-1水平可能能够显示其疾病的严重程度，且TIMP-1降低可能是心肌炎进展为扩张性心肌病的机制之一。Objective To evaluate the relationship between serum tissue inhibitors of metalloproteinase-1 and children with myocarditis, and provide evidences to support the measurement of serum tissue inhibitors of metalloproteinase-1. Methods Tissue inhibitors of metalloproteinase-1 and biochem indexes of the harvested specimens and echocardiogram were measured from children with myocarditis（age： 1 - 14 years old, n = 9） and healthy young children（age： 1-14 years old, n = 9）. Results Children with myocarditis showed reduced ejection fraction and dilated left ventricular compared with healthy children. Tissue inhibitors of metalloproteinase-1 in children with myocarditis was significantly reduced compared with healthy children. Aspartic acid transaminase, lactate dehydrogenase, creatine kinase, hydroxybutyric acid dehydrogenase, MB isoenzyme of creatine kinase, cardiac troponin Ⅰ , C reactive protein showed no difference between two groups. Conclusion The reduced serum level of tissue inhibitors of metalloproteinase-1 may show the severity of children with myocarditis and maybe one of the mechanisms of children with dilated cardiomyopathy following myocarditis.

关 键 词：基质金属蛋白酶组织抑制因子-1 心肌炎 儿童 

分 类 号：R72[医药卫生—儿科]