我院住院癌症患者麻醉性镇痛药使用情况分析  

Analysis of the Use of Narcotic Analgesics in Cancer Sufferers in our Hospital

作　　者：徐红[1] 郭红[1] 张秀明[1] 李文菁[1] 

机构地区：[1]解放军总医院药品保障中心第一临床药局,北京100853

出　　处：《药物流行病学杂志》2008年第4期254-256,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:调查和分析我院住院癌症患者麻醉性镇痛药的应用情况,为临床合理使用麻醉药品提供依据。方法:以 WHO 推荐的 DDD 和 DIU 为指标,对我院2006年住院癌症患者的麻醉性镇痛药处方5009张进行统计分析和评估。结果:处方使用频率分别为硫酸吗啡缓释片18.8%、硫酸吗啡控释片9.2%、盐酸羟考酮控释片13.7%、芬太尼透皮贴剂18.8%、盐酸哌替啶注射液5.1%;除硫酸吗啡缓释片 DUI=1.18、盐酸布桂嗪片 DUI=1.03外,其他 DUI 均≤1。结论:我院麻醉性镇痛药用于癌症患者基本合理,吗啡口服剂型、盐酸羟考酮控释片和芬太尼透皮贴剂已经成为缓解癌症疼痛的首选,盐酸哌替啶注射液不再作为癌痛治疗的选择。Objective： To Investigate and analyze narcotic analgesics used for cancer patients in our hospital and provide a basis for the rational use of narcotic drugs in clinical practice. Method： Defined daily doses （ DDD ） and drug utilization index（DUI） recommended by WHO were used as the judging criteria, 5009 prescriptions of narcotic analgesics collected from the East Hospital Ward Building in our hospital in 2006 were analyzed. Result： The use frequencies of prescriptions were 18.8% of slow-release morphine sulfate, 9.2% of controlled-release morphine sulfate, 13.7% of oxycodone hydrochloride controlled-release Tablets, 18.8% of fentanyl transdermal system, and 5.1% of pethidine hydrochlofide in- jection. The drug utilization index （DUI） was less or equal to 1, except for the slow releasing morphine sulfate DIU = 1.18 and bucinrazine hydrochloride tablets DIU = 1.03. Conclusion： The results suggested that the utilization of anesthetic analgesics for pain relief in cancer patients was essentially rational. The dosage specification of morphine, oxycodone hydrochlofide controlled-release tablets and fentanyl transformal system has become the first choice for pain relief in patients with cancer, and pethidine hydrochloride injection is no longer used as a choice for cancer pain.

关 键 词：麻醉性镇痛药 癌痛 药物利用 药物利用指数 

分 类 号：R971.2[医药卫生—药品]