心复康口服液对心梗后心衰大鼠心肌组织ATP ADP AMP影响的研究  

Effects on content of ATP ADP and AMP in cardiac muscle of heart failure post myocardial infarction in rats by XFK oral liquid

作　　者：胡元会[1] 吴华芹[1] 张百舜[1] 程慧平[1] 何建成[2] 曹雪滨[3] 褚瑜光[1] 王阶[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]上海中医药大学基础医学院,上海201203 [3]解放军第252医院心内科,河北保定071000

出　　处：《辽宁中医杂志》2008年第8期1141-1143,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然基金资助项目(30271619);北京市自然基金资助项目(7042054)

摘　　要：目的:观察心复康口服液对心梗后心衰大鼠心肌组织ATP、AMP、ADP含量的影响。方法:采用结扎SD大鼠左冠状动脉前降支致心梗后心衰大鼠模型,用心复康口服液于术后24h灌胃给药至6周,以卡托普利作为阳性对照药。给药6周后观察大鼠左室梗死周围心肌组织中ATP、ADP、AMP含量。结果:与对照组比较,模型组ATP含量明显降低,而ADP、AMP含量显著升高;与模型组比较,卡托普利、心复康口服液组ATP含量明显升高,ADP和AMP含量明显减少(P<0.01)。结论:心复康口服液可增加心梗后心衰大鼠心肌组织中ATP含量、降低ADP、AMP含量,有效改善心梗后心衰大鼠心肌能量代谢,从而保护心功能。Objective： To observe the effects of Xinfukang（XFK） oral liquid on content of ATP, ADP and AMP in Cadiac muscle of Heart Failure post Myocardial Infarction in rats. Methods ： the AMI models were established by ligating left anterion descending coronary artery and the rats with AM/were ramdonly divided into Model groups, XFK high dose groups, XFK low dose groups and captopril groups. Sham - operated group served as control. After 6 weeks of the treatment, content of ATP, ADP and AMP were determined. Twenty - four hours after establishing models, the rats were fed on XFK oral liquid through the gastrotube for 6 weeks. Results： Comparing with sham group, ATP content of myocardial tissue were obviously lowed in model, ADP and AMP contents were obviously elevated, comparing with model group , the content of ATP in Captopril and XFK groups were obviously increased, but contents of ADP and AMP were obviously reduced （ P 〈 0.01 ）. Conclusions： XFK oral liquid can effectvely inhibit the obstacle of energy metabolism. And protect the cardiac fimction by up - regulation the contents of ATP, synchronously, down - regulation the contents of ADP and AMP.

关 键 词：心复康口服液 高能磷酸化合物 心力衰竭 大鼠 实验研究 

分 类 号：R285.5[医药卫生—中药学]