基于体素的形态测量法分析高功能孤独性障碍患儿的脑组织密度  

Voxel-based morphometric analysis on the density of brain in children with autistic disorder

作　　者：柯晓燕[1] 洪珊珊[3] 邹冰[1] 汤天宇[3] 李惠国[2] 周振宇[3] 杭跃跃[1] 阮宗才[3] 陆祖宏[3] 

机构地区：[1]南京医科大学附属脑科医院儿童心理卫生研究中心,210029 [2]南京医科大学附属脑科医院影像科,210029 [3]东南大学儿童发展与学习科学教育部重点实验室

出　　处：《中华精神科杂志》2008年第3期140-143,共4页Chinese Journal of Psychiatry

基　　金：国家自然科学基金资助项目（30570655）;南京市医学重点科技发展资助项目（ZKX06025）;南京市科技发展计划资助项目（200701109）

摘　　要：目的分析学龄孤独性障碍患儿脑组织密度。方法对17例智能正常的孤独性障碍患儿（病例组）以及15名年龄、性别、智商与之相匹配的健康儿童（对照组）进行T1加权三维磁共振成像扫描，应用基于体素的形态测量法（VBM）比较两组脑灰质及脑白质密度的差异。结果与对照组相比，孤独性障碍患儿右侧小脑前叶的脑灰质密度低，右前扣带回、右额中回区域的脑白质密度低，双侧顶下小叶、右缘上回、右中央后回、右颞上回、右小脑后叶、左楔前叶、左楔叶的脑灰质密度高（P〈0．001）。结论智力正常的学龄孤独性障碍患儿脑组织密度异常明显，且部位广泛。Objective To assess the density difference in the cerebral grey and white matter in children with autistic disorder. Methods Voxel based morphometry （VBM） in conjunction with statistical parametric mapping was applied to the structural magnetic resonance images of 17 autistic disorder children and 15 normal controls. Results Compared with the controls, the grey matter density in autistic disorder children had significant decrease in the right anterior lobe of cerebellum and increase in the bilateral inferior parietal lobule, right supramarginal gyrus, right postcentral gyrus, right posterior lobe of cerebellum, fight superior temporal gyrus, left precuneus and left cuneus （ P 〈 0. 001 ）. Significant clusters of reduced white matter density were found in the region of right anterior cingulated and right medial frontal gyrus （ P 〈 0. 001） in autistic disorder children in comparison with controls. Conclusion The findings indicate structural grey and white matter are significantly abnormal in children with autistic disorder and the deficits are widespread in brain regions.

关 键 词：孤独性障碍 脑 磁共振成像 基于体素的形态测量法 灰质 白质 

分 类 号：R686[医药卫生—骨科学]