厦门地区血培养病原菌分布及耐药性分析  

Distribution and drug resistance of blood culture pathogenic bacteria in Xiamen area

作　　者：房丽丽[1] 宋秀宇[1] 吴维生[1] 王涛[1] 马晓波[1] 朱波[1] 郑燕青[1] 

机构地区：[1]福建医科大学附属厦门第一医院检验科,361003

出　　处：《检验医学与临床》2008年第17期1025-1027,共3页Laboratory Medicine and Clinic

摘　　要：目的了解厦门地区血培养检出的病原菌分布及其对抗菌药物的耐药情况,为临床合理选择抗菌药物提供依据。方法2107例血标本经BacT/ALERT120全自动血培养仪培养检测,检出的病原菌采用VITEK2compact全自动微生物鉴定药敏仪进行细菌鉴定及药敏分析。结果共检出230株病原菌,阳性率为10.9%,其中革兰阳性球菌占38.7%,革兰阴性杆菌占51.7%,真菌占9.6%,葡萄球菌属和肠杆菌科细菌是厦门地区菌血症或败血症的主要病原菌。有43.6%的大肠埃希菌和26.7%的肺炎克雷伯菌产超广谱β-内酰胺酶。结论血培养病原菌种类复杂,耐药率较高,应重视血培养及对血培养病原菌耐药性的监测,合理使用抗菌药物。Objective To investigate the distribution and drug resistance of pathogenic bacteria isolated from blood culture in Xiamen area, in order to provide evidence for rational use of antibiotics in clinic. Methods 2 107 cases of blood samples were cultivated in applying BacT/ALERT 120 automated blood culture system. Then species identification and drug sensitivity test were performed with VITEK 2 compact automated bacteria identification and drug sensitivity analytical system. Results Among the 2 107 blood samples, 230 strains of pathogenic bacteria were isolated. The positive isolating rate was 10.9%. The gram-positive cocci accounted for 38.7%, gram-negative bacilli 51.7%, and fungi were 9.6%. Staphylococcus and Enterobacteriaceae were main pathogens in bacteremia and septicaemia in Xiamen area. ESBLs-producing strains were found in 43.6 % of E. coli isolates and 26.8 % of K. pneumoniae isolates. Conclusion The species of isolated bacteria are complicated from the blood cultures and their drug resistance rate is high. Blood culture and monitoring of drug resistance should be paid emphasized on, which is vital for rational use of antibiotics in clinic.

关 键 词：血培养 病原菌 耐药性 抗菌药物 

分 类 号：R969.4[医药卫生—药理学]