血清尿酸合并高血压对男性冠状动脉狭窄程度的影响  

The effects of serum uric acid complicating with hypertension for the degree of coronary artery stenosis of male patients

作　　者：王培[1] 赵洛沙[1] 杨帆[1] 孔瑞娜[1] 陈艳[1] 

机构地区：[1]郑州大学第一附属医院心内科,郑州450052

出　　处：《中国实用医刊》2008年第15期9-10,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨血清尿酸（SUA）合并高血压对男性冠状动脉狭窄程度的影响。方法随机选择522例，临床诊断为冠心病而行冠状动脉造影的男性患者，按高血压诊断标准分为高血压组（HT）和非高血压组（NHT），比较两组间冠状动脉狭窄积分、SUA及血小板状态[血小板计数（PLT），血小板平均容积（MPV），血小板分布宽度（PDW）]的差异，以探讨SUA合并高血压对冠状动脉狭窄程度的影响。结果冠状动脉狭窄程度、SUA及PDW组间差异有统计学意义（HT〉NHT，P〈0．01；HT〉NHT，P〈0．01；HT〈NHT，P〈0．05）。结论高血压合并高尿酸可能协同影响男性冠心病患者血小板状态，并促进或加速冠状动脉粥样硬化的发展。Objective To discuss the effect of serum uric acid （SUA） complicating with hypertension for the degree of coronary artery stenosis of male patient. Methods 522 male patients with clinical diagnosisas coronary heart diseasewere selected randomlyto adopt coronary arteriography. They were divided into hypertension group （HT） and non - hypertensive group （ NHT）, according to the diagnostic criteria of hypertension. We compared the differences of coronary artery stenosis integral, serum uric acid and the state of platelets [ platelets count （ PLT）, mean platelet volume （ MPV ）, platelet distribution width（PDW） ] between the two groups to explore the effect of hypertension complicating SUA for the degree of coronary artery stenosis. Results Coronary artery stenosis integral, SUA and PDW were significant differences between the two groups （ HT 〉 NHT, P 〈 0.01 ; HT 〉 NHT, P 〈 0.01 ; HT 〈 NHT, P 〈 0.05 ）. Conclusion Hypertension complicating with high SUA maybe have synergistic effects in male patients with coronary heart disease by impacting the state of platelets, and synergistic promoting or accelerating the development of coronary artery atherosclerosis.

关 键 词：尿酸 高血压 冠状动脉造影 血小板 

分 类 号：R543[医药卫生—心血管疾病] R544.1[医药卫生—内科学]