血压正常高值人群血液流变学变化特点及临床意义  

Changes of hemorheology and clinical significance in the subjects with prehypertensive people

作　　者：王晓征[1] 朱江[1] 张丰[1] 聂鑫[1] 解惠玉[1] 郭惠琴[1] 程云[1] 

机构地区：[1]郧阳医学院附属东风医院体检中心,湖北十堰442008

出　　处：《中国实用医刊》2008年第15期23-24,共2页Chinese Journal of Practical Medicine

摘　　要：目的研究血压正常高值人群的血液流变学特性及其临床意义。方法以8842例体检者为研究对象，按血压水平将其分为三组，正常血压组5221例，血压正常高值组1787例，高血压组1834例。分别测定乓总胆固醇（FC）、甘油三酯（TG）、高密度脂蛋白（HDL—C）、低密度脂蛋白（LDL—C）、血糖（GLU）和血液流变学的各项指标。结果血压正常高值组的TC、TG、LDL—C、GLU、全血高切粘度（μbH）、全血中切粘度（μbM）、全血低切粘度（μbL）、血浆粘度、红细胞压积（HCT）、红细胞刚性指数（ERI）均高于正常对照组（P〈0．05），HDL—C低于正常组（P〈0.05），红细胞聚集指数（EAI）和变形指数（TK）两组差异无统计学意义。高血压组的TC、TG、LDL—C、GLU、血浆粘度、ERI、TK均高于正常高值组，HDL—C、μbH、μbM、μbL、HCT、EAI两组差异无统计学意义。结论不仅高血压患者存在高粘血症，在血压正常高值阶段就已经存在明显血液流变学的改变，血液流变学改变可能参与了高血压及其并发症的发生及发展。Objective To observe the changes of hemorheology and clinical significance in the subjects with prehypertensive people. Methods According to blood pressure level 8 842 cases were divided into the control group （ n = 5 221 ）, prehypertensire group （ n = 1 787 ）, EH group （ n = 1 834）. Collected the material of 8 842 cases who attended the physical examination, including blood pressure, plasma lipids, plasma glucose, hemorheology parameters and so on. Results In prehypertensive group, the levels of TC,TG,LDL - C, GLU, μbH, μbM,μbL, plasma viscosity, HCT, ERI were higher than those in control group （ P 〈 0. 05 ） ,but the level of HDL - C was lower（ P 〈 0. 05 ）. The levels of TC, TG, LDL - C, GLU, plasma viscosity, ERI, TK in EH group were higher than those in control group （ P 〈 0. 05 ）. Conclusion Not only hyper viscosity exists in subjects with hypertension, but also in those with prehypertensive. The changes of hemorheology might participate in the occurrence and development of hypertension and vascular complications.

关 键 词：血压正常高值 血液粘滞度 血液流变学 血压水平 高血压 

分 类 号：R446.1[医药卫生—诊断学]