镉作业工人尿中相关指标的研究  

Study of urinary index in cadmium-exposed workers

作　　者：陈敏[1] 班永宏[1] 仲立新[1] 

机构地区：[1]江苏省疾病预防控制中心,南京210028

出　　处：《中国卫生检验杂志》2008年第8期1535-1536,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨慢性职业性镉中毒的早期诊断指标。方法:以职业接触镉工人144人为接触组和未接触镉且体检未见异常的员工114人为研究对象,分别检测尿中镉(Cd)、α1-微球蛋白(α1-MG)、β2-微球蛋白(β2-MG)、视黄醇结合蛋白(RBP)、N-乙酰-β-D-氨基葡萄糖苷酶(NAG)、碱性磷酸酶(AKP)、γ-谷氨酰基转移酶(GGT)的含量,应用SPSS10.0软件进行统计学分析。结果:镉作业工人尿镉含量在各接触组中均增高,尿α1-MG、β2-MG、RBP在接触2、3组中增高,与对照组相比有显著性差异(P<0.05),且随着接触时间的延长呈上升趋势;各接触组尿GGT、NAG活性均明显高于对照组(P<0.05)。结论:尿镉、α1-MG、β2-MG、RBP、GGT、NAG可作为慢性职业性镉中毒的早期诊断指标。Objective： To study the early judgment index in chronic occupational cadmium poisoning.Methods：A total of 144 urine samples of occupationally cadmium-exposed workers and that of 144 in the control were selected for determination of the levels of cadmium（Cd） and α1-microglobulin（α1-MG） andβ2-microglobulin（β2-MG） and retinol blinding protein（RBP） and N-acetyl-β-D-Glucosaminidase（NAG） and alkaline phosphatase（AKP） andγglutamyl transpeptidase（γ-GT）.Results：In the exposed,the Cd levels in every group and the α1-MG and β2-MG and RBP in the group 2 and 3 were significantly higher than those in the control（P〈0.05）,and their levels were positively correlated with the cadmium-exposed time.The γ-GT and NAG levels in every group were significantly higher than those in the control（P〈0.05）.Conclusion：Cd,α1-MG,β2-MG,RBP,γ-GT and NAG are the early judgment indexes in chronic occupational cadmium poisoning.

关 键 词：镉作业 尿镉 尿微量蛋白 尿酶 

分 类 号：R135.1[医药卫生—劳动卫生]