肝损害型毒蕈中毒患者凝血指标检测的临床意义  

Clinical significance of coagulation parameters in liver damage by mushroom poisoning

作　　者：黄媛[1] 陈建魁[1] 宋世平[1] 朱晓华[1] 金欣[1] 尹秀云[1] 

机构地区：[1]军事医学科学院附属医院检验科,北京100071

出　　处：《中国卫生检验杂志》2008年第8期1571-1572,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:了解肝损害型毒蕈中毒患者五项凝血指标的变化,并探讨其在判断肝损伤程度、预后及指导临床治疗中的价值。方法:用美国Beckman Coulter公司ACL-9000全自动凝血/纤溶分析仪测定46例肝损害型毒蕈中毒患者的血浆凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)含量和D二聚体(D-Dimer)水平5项凝血指标。结果:毒蕈中毒死亡组与生存组比较,ALT、PT、APTT、TT均升高(P<0.05或P<0.01),FIB降低(P<0.01)。生存组与正常对照组比较ALT、PT、TT均升高(P<0.05),FIB降低(P<0.05)。生存组与肾功能损害组比较PT、TT升高(P<0.05),FIB降低(P<0.05)。结论:凝血指标PT、APTT、TT、FIB在判断肝损害型毒蕈中毒患者肝损伤程度、预后及指导临床治疗中有一定的价值。Objective： To study the clinical value of coagulation parameters in patient with mushroom poisoning.Methods：Forty-six patients were enrolled.Plasma level of prothrombin time（PT）,activated partial thromboplastin time（APTT）,fibrinogen（FIB）,thrombin time（TT）and D-dimer（DD） were determined using ACL-9000 analyzer.Results：The levels of ALT,PT,APTT and TT were increased and FIB reduced in death group than those in survival group.The levels of ALT,PT and TT were increased and FIB were reduced in survival group than those in controls.Conclusion：The level of PT,APTT,TT and FIB are useful to evaluate liver damage,estimate prognosis and guide treatment.

关 键 词：毒蕈中毒 凝血 肝功能 预后 

分 类 号：R595[医药卫生—内科学]