过量氟和适量硒对新西兰兔血脂及血液流变的影响  

Effects of Overdose Fluoride and Moderate Selenium Intake on Blood Lipid and Hemorheology in Rabbits

作　　者：朱秋丽[1] 樊婷[1] 蔺新英[1] 边建朝 杨晓霞 姜艳艳[1] 

机构地区：[1]山东大学营养与食品卫生学研究所,山东济南250012 [2]山东省地方病防治所,山东济南250014

出　　处：《环境与健康杂志》2008年第7期590-592,共3页Journal of Environment and Health

基　　金：山东省国土资源厅资助项目(1212010310306)

摘　　要：目的研究过量氟对新西兰兔血脂及血液流变的影响及硒的保护作用。方法将20只健康清洁级雄性新西兰兔分为对照组、加氟组(含氟100mg/L)、加硒组(含硒1mg/L)、加氟加硒组(含硒1mg/L,氟100mg/L),以饮水途径自由染毒6个月后检测全血流变、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血清超氧化物歧化酶(SOD)活力、谷胱甘肽过氧化物酶(GSH-Px)活力、血清丙二醛(MDA)含量。结果加氟组新西兰兔血流变各指标异常。与对照组比较,加氟组血清TC、HDL-C、LDL-C水平升高,血清SOD、全血GSH-Px活力降低,血清MDA含量升高。加氟加硒组与加氟组比较上述指标明显改善。结论氟中毒导致血流变异常,脂质代谢紊乱,抗氧化酶活力降低。适量硒可起到一定的保护作用。Objective To study the effects of overdose fluoride on blood lipid and hemorheology in rabbits and the protective effect of selenium. Methods Twenty male rabbits were divided into 4 groups： normal group,fluorine group（100 mg/L）,selenium group（1 mg/L） and selenium （1 mg/L） plus fluorine （100 mg/L） group. After 6 months of treatment,whole blood rheology,blood serum TC,TG,HDL-C,LDL-C,SOD activity,GSH-Px activity,the content of MDA were determined. Results The whole blood rheology of rabbit in fluorine group was abnormal. Compared with the normal group,significant increase of blood serum TC,HDL-C,LDL-C was seen,decrease of SOD activity and GSH-Px activity and increase of the content of MDA in fluorine group was found. The results of selenium plus fluorine group was more close to the normal group compared with fluorine group. Conclusion Fluorosis can induce hemorheology and lipid metabolism disorder and decrease the capacity of antioxidase and moderate selenium intake may have some protective effect.

关 键 词：氟 硒 血脂 血液流变学 

分 类 号：R994.6[医药卫生—毒理学]