雷尼酸锶干混悬剂的HPLC测定  

Determination of Strontium Ranelate for Suspension by RP-HPLC

作　　者：郭仁平 李小敏[1] 张斐[1] 

机构地区：[1]江苏先声药物研究有限公司,江苏南京210042

出　　处：《中国医药工业杂志》2008年第8期615-616,共2页Chinese Journal of Pharmaceuticals

摘　　要：建立了HPLC法测定雷尼酸锶干混悬剂的含量和有关物质。采用C18柱,流动相为水(用磷酸调pH2.0)-乙腈(88∶12),检测波长为238nm。雷尼酸锶在40～400μg/ml浓度范围内线性关系良好,平均回收率为99.1%,RSD为0.47%。A HPLC method was established for the determination of the content of strontium ranelate for suspension and its related substances. A C18 column was used with the mobile phase of water （adjusted to pH 2.0 with phosphoric acid）-acetonitrile （88：12） at the detection wavelength of 238nm. The calibration curve was linear in the range of 40 - 400μg/ml. The average recovery was 99. 1% with RSD of 0.47 %.

关 键 词：雷尼酸锶 高效液相色谱 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.72[化学工程—制药化工]