男性高血压病患者一氧化氮合酶与血尿酸及吸烟关系的临床研究  

Nitric oxide synthase, serum uric acid and smoking history in essential hypertension patients

作　　者：李培秀[1] 李立祥[2] 都日娜[3] 银广悦[4] 史连义[4] 贺海荣[1] 唐晓斌[2] 董志远[2] 张继领[4] 

机构地区：[1]中国石油天然气集团公司中心医院PET/CT,河北省廊坊市065000 [2]中国石油天然气集团公司中心医院心内科,河北省廊坊市065000 [3]中国石油天然气集团公司中心医院心外科,河北省廊坊市065000 [4]中国石油天然气集团公司中心医院检验科,河北省廊坊市065000

出　　处：《中国医药》2008年第9期513-515,共3页China Medicine

基　　金：河北省科学技术研究与发展指导计划资助项目（062761679）

摘　　要：目的研究男性高血压病患者一氧化氮合酶（NOS）活性与血尿酸水平及吸烟指数之间的相关性，为高血压病的发病机制和防治提供理论依据。方法168例男性按有无高血压分为高血压组和对照组，在高血压组内分为吸烟亚组和不吸烟亚组。测定各组NOS和诱导型一氧化氮合酶（iNOS）的活性、血尿酸浓度，计算吸烟指数，并进行比较分析。结果高血压组NOS、iNOS活性均明显低于对照组，血尿酸浓度明显高于对照组，差异有统计学意义（P〈0．05）。高血压组内吸烟亚组和不吸烟亚组血尿酸浓度比较有统计学意义（P〈0．05）。血尿酸与吸烟指数呈正相关（r=0．230，P〈0．05），血尿酸与iNOS呈显著正相关（r=0．568，P〈0．01）。结论血清NOS、iNOS活性、血尿酸浓度和吸烟与高血压病关系密切，在高血压病的发生及发展中血尿酸浓度与吸烟相关、血尿酸与iNOS相关。Objective To observe the correlation among Nitric Oxide Synthase （NOS） activity, Serum Uric Acid （SUA）level and smoking index in male essential hypertension （EH） patients and to provide theoretical evidence for the pathogenesis, prevention and treatment of EH. Methods A total of 168 men were enrolled. Study group included 100 cases who were EH patients and control group had 68 healthy men. According to smoking condition, the study group was subdivided into two groups： smoking group and non-smoking group. The activity of NOS and inducible Nitric Oxide Synthase （iNOS） were determined with chemistry colorimetry. The SUA level was detected with enzymology. Then the smoking index was calculated. Results The general activities of NOS,iNOS of EH patients were significantly lower and SUA of EH patients were obviously higher than that of the control group. The SUA concentrations between the smoking and non-smoking subgroups had a statistical difference （ P 〈 0. 05 ）. The linear correlation analysis showed there was a positive relation between smoking history and serum uric acid level. Simultaneously, there was a positive relation between SUA level and iNOS with a correlation coefficient 0. 568 （P 〈 0. 01）. Conclusion The levels of serum NOS,iNOS activity,UA and smoking history were closely related to EH while The level of SUA was related to smoking history, and SUA is related to iNOS.

关 键 词：高血压病 血尿酸 一氧化氮合酶 诱导型一氧化氮合酶 吸烟指数 

分 类 号：R544.1[医药卫生—心血管疾病]