高血压病患者颈动脉粥样硬化程度与血清脂蛋白(a)和胆红素水平的关系  

Relationship Between Serum Bilirubin and Lipoprotein(A) with Carotid Artery Atherosclerosis in Hypertensive Patients

作　　者：刘艳[1] 陈爱芳[2] 李秀昌[1] 

机构地区：[1]泰山医学院附属医院心内科,山东省泰安市271000 [2]泰山医学院附属医院超声科,山东省泰安市271000

出　　处：《中国动脉硬化杂志》2008年第7期553-555,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨血清脂蛋白(a)和胆红素水平变化与颈动脉粥样硬化程度的关系。方法选择高血压病患者124例,进行颈动脉超声检查,根据颈动脉粥样硬化程度(狭窄)程度分为内膜增厚组、内膜斑块形成组、管腔轻度狭窄组、管腔中度狭窄组和管腔重度狭窄组5组,同时检测血清脂蛋白(a)和胆红素水平,并进行统计学分析。结果颈动脉粥样硬化程度加重时,在5组血清脂蛋白(a)分别为156.7±89.2mg/L,237.0±170.3mg/L,324.0±126.0mg/L,331.9±197.5mg/L和346.2±124.0mg/L,前3组间差异有显著性(P<0.05),血清总胆红素分别为12.4±2.6μmol/L,10.7±1.4μmol/L,9.1±1.0μmol/L,8.1±0.9μmol/L和7.1±0.8μmol/L,间接胆红素分别为9.1±2.4μmol/L,7.4±1.5μmol/L,5.9±1.2μmol/L,4.9±0.8μmol/L和3.9±0.8μmol/L,5组间差异有显著性(P<0.01),而直接胆红素差异无显著性(P>0.05)。脂蛋白(a)与总胆红素、间接胆红素水平显著负相关(r=-0.332和-0.331,P均<0.01)。结论高血压病患者的血清脂蛋白(a)和胆红素水平变化与动脉粥样硬化关系密切。Aim To explore the association of serum lipoprotein（a） and serum bilirubin with carotid atheroselerosis in patients with hypertension. Methods 124 patients with hypertension whose carotid atheroselerosis were detected by ultrasound were divided into increased IMT group, atheroma group, mild stenosis group , moderate stenosis group, and severe stenasis group. The serum hpoprotein（a） and serum bilirubin levels were measured using automatic biochemistry analysis system. Results Those patients with more severe carotid atheroselerosis had higher serum lipoprotein （a） and lower serum total bilirubin and serum indirect bilirubin. The level of lipoprotein （a） among five groups above （ 156.7 ± 89.2 mg/L, 237.0 ± 170.3 mg/L, 324.0 ± 126.0 mg/L, 331.9 ± 197.5 mg/L and 346.2 ± 124.0 mg/L）was significant statistical difference （ P 〈 0.05）. So were serum total bilirubin （ 12.4 ± 2.6 μmol/L, 10.7 ± 1.4 μmol/L, 9.1 ± 1.0 μmol/L, 8.1 ± 0.9 μmol/L and 7.1 ± 0.8 μmol/L） and serum indirect bilirubin （ 9.1 ± 2.4 μmol/L, 7.4 ± 1.5 μmol/L, 5.9 ± 1.2 μmol/L, 4.9 ± 0.8 μmol/L and 3.9 ± 0.8 μmol/L）. While Serum direct bilirubin showed no statistical difference between five groups （ P 〉 0.05 ）. Otal and indirect serum bilirubin correlated negatively with lipoproteh,（a） （r= -0.332and -0.331, P〈0.01 forall）. Conclusion High serum lipoprotein（a） and low serum bilirubin may be closely related to atheroselerosis in patients with hypertension.

关 键 词：内科学 颈动脉 动脉粥样硬化 血清脂蛋白(a) 血清胆红素 高血压病 

分 类 号：R5[医药卫生—内科学]