大孔聚乙烯醇胺化树脂的制备及吸附胆红素性能评价  

Preparation of Aminated Macroporous Polyvinyl Alcohol Resins and Evaluation for Bilirubin Adsorption

作　　者：张胜男[1] 王为超[2] 胡月晗[2] 谢慧[2] 欧来良[2] 俞耀庭[2] 孔德领[2] 顾汉卿[1] 

机构地区：[1]天津医科大学,天津300070 [2]南开大学生物活性材料教育部重点实验室,天津300071

出　　处：《透析与人工器官》2008年第2期1-5,共5页Chinese Journal of Dialysis and Artificial Organs

摘　　要：本文制备了大孔聚乙烯醇树脂,固定8种胺化试剂作为配基,制备了一系列胆红素吸附剂。通过体外静态和动态吸附实验对胆红素吸附性能进行了系统的评价。结果表明,该类吸附剂对胆红素具有较高的吸附效率和吸附容量,其中以三甲胺、三乙胺和1,6-己二胺为配基的吸附剂吸附效果最佳,在30min内可达到吸附平衡,对胆红素的清除率达到80%以上。吸附机制以静电作用和疏水作用为主,呈单分子层物理吸附。该吸附剂具有良好的临床应用前景。The authors prepared macroporous polyvinyl alcohol beads in the present study, A series of bilirubin adsorbents were generated by immobilization of 8 amine agents to the beads as ligands. The adsorption of bilirubin was evaluated by in vitro static and dynamic adsorption tests. The results show that these adsorbents had excellent adsorption efficiency and capacity. Among the eight ligands for example, trimethylamine （TMA）, triethylamine （TEA） and 1 ,6-hexanediamine（HDA） , showed the highest adsorption capacity. The adsorption equilibrium can be achieved in a half hour, and the adsorption rate of bilirubin was up to 80%. Static electricity and hydrophobic interaction play an important role in bilirubin adsorption, and the adsorption was found to match the monolayer model. The excellent adsorption of these adsorbents indicates their potential in clinical treatment.

关 键 词：大孔聚乙烯醇树脂 胺化树脂 胆红素 吸附剂 血液净化 

分 类 号：R318.08[医药卫生—生物医学工程]