肝移植术后受体移植术后糖尿病、HCMV、HBV相关性研究  

Association of post transplantation diabetes mellitus to active human cytomegalovirus infection and preoperative hepatitis B virus infection： analysis of 75 cases

作　　者：张旋[1] 范骏[1] 陈晓明[1] 高海女[1] 杨美芳[1] 赵宏[1] 马伟杭[1] 

机构地区：[1]浙江大学医学院附属第一医院传染病诊治国家重点实验室,杭州310003

出　　处：《中华医学杂志》2008年第29期2053-2055,共3页National Medical Journal of China

基　　金：国家自然科学基金资助项目（30471631）

摘　　要：目的研究移植术后糖尿病（PTDM）与人巨细胞病毒（HCMV）活动性感染、术前乙型肝炎病毒（HBV）感染的关系。方法回顾性分析75例肝移植患者临床资料，观察患者PTDM的发生、移植术后HCMV活动性感染及术前HBV感染的情况。结果PTDM发生率为17．3％（13／75）。术后HCMV活动性感染组PTDM发生率（23．1％）明显高于无活动性感染组（4．3％）（P〈0．05）。术前HBV感染者PTDM发病率较未感染者高（21．1％与5．6％，P〉0．05）。结论PTDM的发生可能与术后HCMV活动性感染有关，与术前HBV感染无关。Objective To investigate the relationship of post transplantation diabetes mellitus （PTDM） to active human cytomegalovirus （HCMV） infection and to preoperative hepatitis B virus （HBV） infection respectively. Methods The clinical data of 75 patients with liver transplantation was collected to analyze the association of PTDM with active HCMV infection and preoperative HBV infection. Results The incidence of PTDM was 17. 3% （ 13/75 ）. The incidence of PTDM in the patients with active HCMV infection after liver transplantation was 23.1% （12/52） significantly higher than that of the patients without active HCMV infection（4.3%, 1/23, P 〈0.05）. The incidence of PTDM in the patients with preoperative HBV infection was 21.1%, not significantly different from that of the patients without infection（5.6%, P 〉 0.05 ）. Conclusion PTDM may be related to active HCMV infection after liver transplantation, and unrelated to preoperative HBV infection.

关 键 词：肝移植 巨细胞病毒属 肝炎病毒 乙型 

分 类 号：R686[医药卫生—骨科学]