肿瘤抑制因子P33ING1b在尖锐湿疣中的表达  

The Expression of Tumour Suppresson p33ING1b in Lesions of Condyloma Acuminaturm

作　　者：陈兴平[1] 贺琪[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院皮肤科,湖北武汉430030

出　　处：《中国皮肤性病学杂志》2008年第8期467-469,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨肿瘤抑制因子P33ING1b在尖锐湿疣(CA)皮损角质形成细胞中的表达。方法取30例CA皮损和10例正常包皮的石蜡标本切片,采用SABC免疫组化法检测其P33ING1b的表达;在临床分别取10例新鲜CA皮损和正常包皮标本,提取组织蛋白后采用Western blot免疫印迹法检测其P33ING1b的表达。结果所有标本免疫组化均检出P33ING1b阳性细胞,CA组P33ING1b的表达与正常对照组相比均显著升高(P<0.01)。结论CA皮损角质形成细胞中P33ING1b的表达异常可能与CA的发生、发展有关。Objective To investigate the expression of tumour suppressor P33ING1b in lesions of condyloma acuminatum （CA）. Methods Taking paraffin sections of 30 CA tissues and 10 normal foreskins for preparation. Using immunohistochemical staining to evaluate P33INGlb expression. Taking 10 fresh essays of CA and normal foreskins from clinic, using western blot protenin detection to estimate the expression of P33ING1b. Results P33INGlb expression in CA was obviously higher than that in normal tissues（P 〈 0.01 ）. Conclusion Abnormal expression of P33ING1 b may play an especial role in the development and progression of CA.

关 键 词：尖锐湿疣 人类乳头瘤病素 P33ING1B 免疫印迹 免疫组化 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]