β_2-微球蛋白在癌性和结核性胸腔积液鉴别诊断中的意义  

Singnificance of β2microglobulin in differential diagnosis of malignant and tuberculous pleural effusion

作　　者：郭伟强[1] 李超乾[2] 

机构地区：[1]南宁市第四人民医院结核病科 [2]广西医科大学一附院呼吸内科

出　　处：《广西医学》1997年第6期949-951,共3页Guangxi Medical Journal

摘　　要：用放射免疫分析法（ＲＩＡ）检测３１例癌性胸水和４０例结核性胸水病人的血和胸水中β２－ＭＧ含量，发现胸水中结核组β２－ＭＧ含量（３．７１０±０．８０９ｍｇ／Ｌ），比癌性组含量（２．９２７±１．２２５ｍｇ／Ｌ）高（Ｐ＜０．０１），两组血清β２－ＭＧ含量虽较正常明显升高（Ｐ＜０．０１），但结核和癌性组间则无区别（Ｐ＞０．０５），两组β２－ＭＧ胸水／血清比值也无统计学差别；结核组胸水β２－ＭＧ含量比其血清含量高（Ｐ＜０．０１），而癌性组则无统计差别；提示同时检测血清和胸水中的β２－ＭＧ含量在结核和癌性胸腔积液的鉴别上有一定意义。Radioimmunoassay (RIA) was applied to detect the concentrations of β2microglobulin in sera and pleural effusion from 31 patients with malignant pleural effusion and 40 patients with tuberculous pleural effusionIt was found that concentration of β2microglobulin in pleural effusion from tuberculous group (3710±0809mg/L) was significantly higher than that from cancer group(2927±1225mg/L,P<001)Although serum β2microglobulin levels in both groups were higher than those in normal control group (P<001),there was no difference between tuberculous and malignant groups(P>005)And no difference of β2microglobulin pleural effusion/serum ratio could be observed between tuberculous and malignant groupsPleural effusion β2microglobulin level was higher than serum β2microglobulin level in tuberculous group,but not in malignant groupThese data suggested that homochronous detection of β2microglobulin in pleural effusion and serum would be of help in differential diagnosis of malignant and tuberculous pleural effusion

关 键 词：胸腔积液 癌性 结核性 鉴别诊断 Β2-微球蛋白 

分 类 号：R442.9[医药卫生—诊断学] R561.304[医药卫生—临床医学]