粒细胞集落刺激因子在急性尿路感染中的变化与意义  

Serum Granulocyte Colony-stimulating Factor Levels in Patients with Acute Urinary Infections

作　　者：许宏岳[1] 李爱红[1] 汪晓秾[1] 姚刚[2] 

机构地区：[1]南京医科大学第二附属医院中心实验室,210011 [2]南京医科大学第二附属医院肾脏内科,210011

出　　处：《天津医药》1997年第12期724-726,共3页Tianjin Medical Journal

摘　　要：应用ELISA法检测42例急性尿路感染患者血清粒细胞集落刺激因子(G-CSF)水平,并动态观察了急性期(①)、应用抗菌药物治疗后第2天(②)及治愈后(③)的不同改变。结果上述3个时期血清G-CSF水平(x±s)分别为(1047.0±676.2)、(565.1±408.3)、(145.6±58.1)ng/L,25例对照组为(122.5±41.9)ng/L。统计分析表明:不同病程3个时期之间均存在极显著性差异(均P<0.01);①、②与对照组间差异也均具极显著性(均P<<0.01);③与对照组差别无统计学意义(P>0.05)。另外,急性期G-CSF水平与外周血中性粒细胞数呈正相关(r=0.48,P<0.05)。而不同感染部位和初诊时体温是否升高,G-CSF变化差异无显著性(均P>0.05)。In 42 patients, serum granulocyte colony-stimulating factors (G-CSF) were studied at the various periods of acute infections two days after treatment and after complete cure. The results (x ± s) were (1 047. 0 ± 676. 2), (565. 1 ± 408. 3)and(145. 6 ± 58. l)ng/L respectively. The controls'were (122. 5 ± 41. 9)ng/L. Statistical analysis indications: There were .highly significant differences between G-CSF levels at different periods (P<0. 01) ; There were highly significant differences among G-CSF levels of acute infections two days after treatment and the controls (P<0. 01); There were no statistical differences between the cured and the controls (P<0. 05). Moreover,G-CSF levels at acute infections had positive association with the counts of the blood neutrophilic granulocyte (r=0. 48,P<0. 05). But the G-CSF levels at different localities and different body temperatures had no significant differences (P< 0.05).

关 键 词：尿路感染 G-CSF 中性粒细胞数 泌尿道感染 

分 类 号：R691.3[医药卫生—泌尿科学]