原发性肝癌患者血清细胞多肽生长因子测定的临床意义  

Clinical Significance of Determination of Serum TGF-α,TGF-β_1,VEGF and TNF-α Levels in Patients with Primary Hepatocellular Carcinoma

作　　者：朱宝[1] 

机构地区：[1]江苏省无锡市人民医院核医学科,214023

出　　处：《放射免疫学杂志》2008年第4期300-302,共3页Journal of Radioimmanology

摘　　要：目的:探讨肝硬化、肝癌患者血清细胞多肽因子测定的临床意义。方法:32例肝癌、34例肝硬化患者及30名对照组人员的血清TGF-α、TGF-β1、TNF-α三项指标采用放射免疫分析(RIA);VEGF水平采用酶联免疫分析(ELISA)。结果:肝癌患者组血清四项指标均显著高于肝硬化及正常对照组(P均<0.05),肝硬化组血清TGF-α、TGF-β1、VEGF水平略高于正常对照组,但均无显著性差异(P均>0.05),TNF-α明显高于正常对照组,差异具显著性(P<0.05)。结论:细胞多肽生长因子TGF-α、TGF-β1、VEGF及TNF-α水平的变化,可促进肝癌细胞的增殖活性,加速肿瘤细胞的生长。提示上述四项指标的变化与肿瘤的发生、发展关系密切。Objective To explore the clinical significance of changes of several serum eytokines levels in patients with hepatoeel-lular carcinoma. Methods Serum levels of TGF -α, TGF - β1, TNF - α （ with RIA） and VEGF （ with ELISA） were determined in 32 patients with primary hepatic carcinoma （ PHC）, 34 patients with hepatic cirrhosis and 30 controls. Results Level of the 4 eytokinos in patients with PHC were significantly higher than those in patients with cirrhosis and controls. Levels of TGF - α, TGF - β1, VEGF in patients with cirrhosis were slightly higher than those in controls but no significant. Levels of TNF - α was higher in patients with cirrhosis （ P 〈 0.05）. Conclusion Over expression of TGF - α, TGF - β1, VEGF and TNF -α increase the proliferation activity of hepatoma carcinoma cell and accelerate the growth of tumor. Changes of the 4 eytokine levels were related to the development of tumor.

关 键 词：肝癌 肝硬化 转化生长因子-Α 转化生长因子-Β1 血管内皮生长因子 肿瘤坏死因子-Α 

分 类 号：R512.62[医药卫生—内科学] R697.320.2[医药卫生—临床医学]