检测leptin、IGF-Ⅰ、IGF-BP_3、E_2、T在肥胖儿发育中的临床意义  

Clinical Significance of Measurements of Serum Leptin and IGF-I,IGF-BP_3,E_2,T Levels in Children with Simple Obesity

作　　者：魏佳玲[1] 宋媛[1] 杜香[1] 汪宪平[1] 杨辰[1] 

机构地区：[1]江苏省苏州市立医院,215002

出　　处：《放射免疫学杂志》2008年第4期374-375,共2页Journal of Radioimmanology

摘　　要：目的:研讨学龄前肥胖和非肥胖儿童的瘦素与内分泌激素水平。方法:检测(3～6)岁122例单纯性肥胖儿童与61例非肥胖儿童的瘦素(leptin)、胰岛素样生长因子I(IGF-I)、胰岛素样生长因子结合蛋白-3(IGF-BP3)、雌二醇(E2)、睾酮(T)水平。结果:肥胖儿童的leptin、IGF-I、IGF-BP3、E2水平均显著高于各自非肥胖儿童组(P均<0.01)。T水平两组间无显著差别(P>0.05)。结论:学龄前单纯性肥胖儿童存在leptin抵抗和内分泌代谢紊乱,检测leptin、IGF-I、IGF-BP3、E2、T对单纯性肥胖症的早期干预有着重要的临床意义。Objective To study the clinical significance of measurements of serum lepfin IGF - I, IGF - BP3, E2, T levels in preschool children with simple obesity. Method,s Serum levels of leptin, insulin - like growth factor I（ IGF - I）, Insulin - like growth factor combined protein 3（ IGF - BP3 ） （ with ELISA） and estradiol （E2 ）, testosterone（T） （ with CLIA） were determined in 122 preschod children with simple obesity and 61 （ matched controls）. Results The serum levels of leptin, IGF - 1, IGF - BP3 and E2 in obese children were significantly higher than those in the controls （ P 〈 0.01 ）, the serum levels of T were not much different from those in controls （P 〉 0.05）. Conclusion There were leptin resistance and metabolic disturbance in obese children. Determination of the levels of leptin and related factors was of great importance for implementation of early intervention in these children.

关 键 词：瘦素 胰岛素样生长因子-I 胰岛素样生长因子结合蛋白-3 雌二醇 睾酮 单纯性肥胖症 学龄前儿童 

分 类 号：R725.892[医药卫生—儿科] R581[医药卫生—临床医学]