食管、贲门癌术后感染危险因素研究  

Risk Factors of Infection after Esophageal and Cardiac Cancer Surgery

作　　者：刘尚国[1] 赵宝生[1] 吕靖民[1] 秦秀广[1] 齐博[1] 卢建国[1] 

机构地区：[1]河南新乡医学院第一附属医院胸外科,河南卫辉453100

出　　处：《中华医院感染学杂志》2008年第8期1096-1098,共3页Chinese Journal of Nosocomiology

摘　　要：目的研究食管、贲门癌术后感染的危险因素,为预防与控制术后感染提供科学依据。方法回顾分析医院2004年8月-2006年12月行食管、贲门癌根治术的512例患者,分析患者的性别、年龄等15项变量与术后感染的关系,用2χ检验和四格表检验作单因素分析,用Logistic回归作多因素分析。结果食管、贲门癌术后感染率为11.13%,单因素分析发现糖尿病、吸烟、呼吸系统疾病、手术方式、发热、术后白细胞等与术后感染有显著的关联(P<0.05),而性别、年龄、手术时间、血红蛋白、肿瘤TNM分期、心血管疾病等与感染的发生无显著关联;多因素分析筛选出4个术后感染的相关因素:吸烟、呼吸系统疾病、手术方式、发热,差异有统计学意义(P<0.05)。结论吸烟、呼吸系统疾病、手术方式、发热与食管、贲门癌术后感染有关,手术前后积极采取必要的措施,可降低术后感染的发生率。OBJECTIVE To investigate the risk factors of postoperative infections of patients after performing an operation with esophageal and cardiac carcinoma, and provide evidence of infection control. METHODS Totally 512 patients after performing an operation with esophageal and cardiac carcinoma from Aug 2004 to Dec 2006 were retrospectively analyzed. Fifteen risk factors （sex, age, etc） were investigated. X^2 Test and cross-tabulation test were used to process the single factor. Logistic regression analysis was used to process the multivariate factors. RESULTS Postoperative infection rate in esophageal and cardiac carcinoma surgery was 11.13%. Univariate Logistic regression analysis indicated that 6 variables were significantly related to the likelihood of postoperative infections （P〈0. 05）： diabetes, smoking, disease of respiratory system, type of operation, fever, and postoperative WBC. However, postoperative infection rate was not closely related to the patientsr sex and age, duration of operation, tumors, TNM pathologic stage, heart disease, etc （P〉0.05）. Multivariate analyses found that 4 variables were related to postoperative infections （P〈0.05） ： smoking, disease of respiratory system, type of operation, and fever. CONCLUSIONS Smoking, disease of respiratory system, type of operation, and fever were closely related to postoperative infections in esophageal and cardiac carcinoma surgery. It can decrease the incidence of postoperative infections to take some necessary prevention measures preoperatively and postoperatively.

关 键 词：危险因素 医院感染 食管癌 贲门癌 

分 类 号：R619.3[医药卫生—外科学]