综合医院主要病原菌耐药性调查  

Mainl Drug-resistant Bacteria in a General Hospital:An Investigation

作　　者：李荡[1] 张丽荣[2] 王晓凤[3] 黄文静 

机构地区：[1]吉林大学中日联谊医院保健科,吉林长春130033 [2]吉林大学中日联谊医院病理科,吉林长春130033 [3]吉林大学中日联谊医院乳甲外科,吉林长春130033 [4]吉林省伊通卫校教研室,吉林伊通136000

出　　处：《中华医院感染学杂志》2008年第8期1150-1151,共2页Chinese Journal of Nosocomiology

基　　金：国家科技攻关项目(2004BA72DA09)

摘　　要：目的监测医院感染病原菌及耐药性,为控制病原菌耐药的传播提供依据。方法对2005、2006年住院1180份病历进行调查与分析。结果2年检出医院感染病原菌170株,位于前5位依次为铜绿假单胞菌、表皮葡萄球菌、白色假丝酵母菌、金黄色葡萄球菌、大肠埃希菌,铜绿假单胞菌占首位,耐药性严重;MRSA和MRCNS对万古霉素敏感率达100.0%,对苯唑西林、青霉素、阿莫西林/克拉维酸100.0%耐药;大肠埃希菌及肺炎克雷伯菌产ESBLs对多种抗菌药物产生多药耐药性。结论病原菌耐药性逐年增加,且产生多药耐药性,应加强临床合理用药,控制耐药性的增加。OBJECTIVE Through the investigations of the pathogen monitoring and drug resistance, we find the evidence for controlling the spread of bacterial drug resistance. METHODS The medical hospital of 1180 patient cases frim 2005 to 2007 were retrospectively investigated and analyzed. RESULTS For recent two years there were isolated 170 strains of pathogenic bacteria and the top five were Pseudomonas aeruginosa, Staphylococcus epider-midis, Candida albicans, Staphylococcus aureus and Escherichia coli. P. aernuginosa was in the first place and its drug rssistance was severe. The sensitive ratio of MRSA and MRCNS to vancomycin was 100% and their resistance ratio to oxacillin, penicillin, amoxicillin/clavulanic acid and ampicilin/sulbactam was 100%; The E. coli and in ESBLs-producting Klebsiella pneumoniaehad multidvug vesistance to various kinds of antibacterials. CONCLUSIONS The resistance of the pathogenic bacteria is increasing year by year, and the multi-drug resistance is also seen, we should use the antibiotic properly in clinicsl to control the increase in bacterial drug resistance.

关 键 词：病原菌 耐药性 调查 

分 类 号：R378[医药卫生—病原生物学]