既往有偿供血感染艾滋病者合并弓形虫感染状况研究  

Study on co-infection with toxoplasma among HIV-infected individuals as previous irregular plasma/blood donors

作　　者：马燕[1] 徐臣[2] 邬超[1] 陈家旭[3] 周晓农[3] 汪宁[1] 丁心平[2] 苏斌[4] 王建军[4] 徐建青[1] 阮玉华[1] 张晓燕[1] 邵一鸣 

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心,北京100050 [2]阜阳市疾病预防控制中心,安徽阜阳236000 [3]中国疾病预防控制中心寄生虫病预防控制所,上海200025 [4]安徽省疾病预防控制中心,合肥230061

出　　处：《中国艾滋病性病》2008年第4期365-367,共3页Chinese Journal of Aids & STD

基　　金：卫生部应用性课题(WA200601)经费资助;CIPRA项目(U19AI051915)

摘　　要：目的了解安徽省既往有偿供血艾滋病病毒(HIV)感染者合并弓形虫感染状况,及其对艾滋病疾病进展的影响。方法以招募的安徽省既往有偿供血员HIV阳性感染者为研究对象,采集外周血,分离血浆,通过酶联免疫吸附试验(ELISA)检测弓形虫抗体。同时检测CD4T细胞和血浆病毒载量的水平。结果在招募的367例中,合并弓形虫感染者11例,感染率为3.0%,主要存在于CD4+T细胞数量低于200/mm3的感染者中。合并弓形虫感染者的CD4+T细胞数低于HIV单一感染者,而病毒载量则呈相反趋势。结论对晚期HIV感染者的管理,在监测CD4+T细胞的同时,应加强监测弓形虫的混合感染,以把握预防用药的合理时机,降低混合感染造成的死亡。Objective To investigate co-infection among HIV-infected individuals who were previous irregular plasma/ blood donors（PBDs）in Anhui province. Methods HIV infected PBDs were recruited as subjects under study from March, 2004 to March,2005 in Anhui province. Blood samples were collected to test toxoplasma infections with ELISA method and CD4^＋ T cells and plasma viral load were measured simultaneously as indicators of progress of HIV/AIDS. Result Of 367 investigated PBDs, 11 individuals were confirmed as co-infected with toxoplasma（3 % ）.Comparing to the group of HIV mono-infection, the patients in the group with HIV/Toxoplasma co-infection had lower CD4^＋T cells counts, but higher plasma viral load, especially when the patients had CD4^＋ T cells near or below 200 cells/1, though the difference was not statistically significant. Conclusion Our study suggests that the management of AIDS patients should also include monitoring of life threatening AIDS related co-infection such as toxoplasma in order to use prophylactic medicines in good time and reduce deaths caused by this co-infection.

关 键 词：艾滋病 弓形虫 合并感染/混合感染 

分 类 号：R512.91[医药卫生—内科学]