2型糖尿病患者代谢综合征与亚临床炎症因子的相关性  

Relationship between Metabolic Syndrome and Subclinial Inflammatory Factors in Type 2 Diabetes

作　　者：程静丽[1] 赵伟[1] 张宏[1] 刘佳[1] 肖洁[1] 张丽[1] 窦红梅[1] 

机构地区：[1]天津医科大学代谢病医院卫生部及天津市激素与发育实验室,天津300070

出　　处：《中国慢性病预防与控制》2008年第4期368-370,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨超敏C-反应蛋白(hs-CRP)、白细胞(WBC)、纤维蛋白原(FIB)等亚临床炎症因子与2型糖尿病患者代谢综合征(MS)的相关性。方法对323名住院的2型糖尿病患者根据临床资料分为MS组和非MS组,分析两组间WBC、hs-CRP、FIB变化及其与MS的相关性。结果MS组较非MS组WBC、hs-CRP、FIB水平增加,差别有统计学意义(P<0.05或P<0.01),且随着MS组分的增加而增加,在调整了年龄、性别、可追溯糖尿病病史、吸烟史后,WBC、hs-CRP、FIB仍与MS独立相关。结论作为亚临床炎症因子的WBC、hs-CRP、FIB与MS存在较强的相关性,这些炎症指标可用于MS的评估。Objective To investigate the changes of the levels of high sensitivity reactive protein C （hsCRP）, white blood cell （WBC） and fibrinogen （FIB） in type 2 diabetic patients with metabolic syndrem （MS）. Method 323 inpatients with type 2 diabetes were divided into MS group and non-MS group according to their clinical dates, and the changes of the levels of hsCRP, WBC and FIB in the two groups and the relationship between their levels and MS were analyzed. Results Compared to non-MS group, the levels of hsCRP, WBC, FIB in MS group were increased obviously （P〈0.05 or P〈0.01）, and the levels increased with number of MS components. After adjusted by age, gender, accessible diabetic history and smooking, the levels of WBC, hsCRP, FIB were still independently correlated with MS. Conclusion The levels of WBC, hsCRP, FIB are closely related with MS. These subclinical inflammatory index can be used for evalutation of MS.

关 键 词：代谢综合征 糖尿病 2型 白细胞 C-反应蛋白 纤维蛋白原 

分 类 号：R587.1[医药卫生—内分泌]