索法酮固体分散体的制备及体外溶出特性  

Preparation and dissolution property of sofalcone solid dispersion

作　　者：杨向平[1] 王文喜[2] 周燕燕[2] 吴文浩[2] 

机构地区：[1]浙江省人民医院,浙江杭州310024 [2]浙江工业大学药学院,浙江杭州310032

出　　处：《中国医院药学杂志》2008年第15期1268-1271,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:制备索法酮固体分散体并考查其体外溶出特性。方法:以PEG2000、PEG4000和PEG6000为载体,采用熔融法制备固体分散体,与物理混合物比较体外溶出度。结果:PEG4000和PEG6000制得的固体分散体的体外溶出度高于PEG2000,均高于物理混合物。载体比例越大,体外溶出越快。结论:以PEG为载体,采用熔融法可制得体外溶出较快的索法酮固体分散体。OBJECTIVE To prepare sofalcone solid dispersion and to investigate its dissolution rate in vitro. METHODS The sofaleone solid dispersion was prepared by melting method with PEG 2000,PEG 4000 and PEG 6000 as carriers. The dissolution rate in vitro was determined and compared with the simple mixture. RESULTS The dissolution of sofaleone solid dispersion prepared by PEG 4000 or PEG 6000 was faster than those prepared by PEG 2000, which was faster than the simple mixture. The dissolution rate was enhanced with the ratio of carriers increased. CONCLUSION The sofaleone solid dispersion prepared by melting method with PEG as carriers has a rapid dissolutionproperty.

关 键 词：索法酮 固体分散体 溶出速率 聚乙二醇 

分 类 号：R943[医药卫生—药剂学]