环钯化二茂铁亚胺卡宾络合物的合成、表征及其对Buchwald-Hartwig胺化反应的催化性质  

Synthesis,Characterization and Catalytic Activity of Cyclopalladated Ferrocenylimine Carbene Complex in Buchwald-Hartwig Amination

作　　者：李敬亚[1] 吴养洁[1] 韩自省[1] 姜松[1] 

机构地区：[1]郑州大学化学系 河南省化学生物与有机化学重点实验室 河南省高校应用化学重点实验室,郑州450052

出　　处：《高等学校化学学报》2008年第8期1555-1559,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20472074,20772114);河南省杰出人才创新基金(批准号:0621001100)资助

摘　　要：合成了一个新的二茂铁亚胺环钯化卡宾络合物,并经过IR,1HNMR,13CNMR,HRMS和X射线衍射对其单晶结构进行鉴定.新合成的催化剂对空气和湿气都很稳定,并且对氯代苯参与的Buchwald-Hartwig胺化反应有较好的催化活性,在摩尔分数为0.5%的催化剂用量下,3h即可以达到中等以上的收率.The palladium-catalyzed amination of aryl halides （Buchwald-Hartwig amination） is a rapidly developing field due to the importance of the products in many fields, e.g. pharmaceuticals, xerography, electronic materials and ligands for transition metals. In this article, a novel cyclopalladated ferrocenylimine carbene complex 3 was conveniently synthesized and characterized via IR,^ 1H NMR, ^13C NMR, HRMS and X-ray single crystal diffraction. Compound 3 was stable to air and moisture in both the solid state and solution. It was successfully applied for the Buchwald-Hartwig amination of aryl chlorides. Using 0. 5 % （molar fraction） of catalyst 3, in the presence of 2 equiv of BuOK as a base in dioxane at 110 ℃ for 3 h, a variety of aryl chlorides and amines could be coupled to afford the coupled products in moderate or excellent yields.

关 键 词：二茂铁亚胺环钯化合物 氮杂环卡宾 胺化反应 芳基氯 

分 类 号：O625.631[理学—有机化学] O614.823[理学—化学]