乙醇对糖尿病易感患者血清肿瘤坏死因子-α、白介素-1、白介素-6、谷氨酸脱羧酶抗体水平的影响  

The effect of alcohol on TNF-α,IL-1,IL-6,GADA in high risk for diabetes mellitus

作　　者：刘敬波[1] 王连文[1] 王秀云[2] 王树云[3] 

机构地区：[1]滨州医学院附属医院核医学科,滨州市256603 [2]滨州医学院附属医院内分泌科,滨州市256603 [3]滨州医学院附属医院脊柱外科,滨州市256603

出　　处：《滨州医学院学报》2008年第4期256-257,261,共3页Journal of Binzhou Medical University

摘　　要：目的观察糖尿病易感患者酗酒时血清肿瘤坏死因子-α(TNF-α)、白介素-1(IL-1)、白介素-6(IL-6)、谷氨酸脱羧酶抗体(GADA)水平的变化。方法选择一组(n=62)有糖尿病家族史的酗酒者体重指数和血脂正常为A组(n=28)、有糖尿病家族史的酗酒者体重指数和血脂升高为B组(n=34)、2型糖尿病患者为C组(n=23)、正常对照组为D组(n=21),分别测定血清TNF-α、IL-1、IL-6、GADA水平的变化,有糖尿病家族史的酗酒者停酒3个月后再次检测血清TNF-α、IL-1、IL-6、GADA水平的变化。组间均数比较采用t检验。结果A组患者酗酒时血清TNF-α、IL-1、IL-6、GADA水平高于D组(P<0.05),B组血清TNF-α、IL-1、IL-6、GADA水平高于D组(P<0.05),C组患者血清TNF-α、IL-1、IL-6、GADA水平明显高于D组(P<0.01);糖尿病易感患者酗酒者在停酒3月后再次检测血清TNF-α、IL-1、IL-6、GADA水平下降(P<0.05)。结论糖尿病易感患者酗酒时乙醇诱发和/或加重胰岛素抵抗、胰岛β细胞的损伤,由此导致糖代谢紊乱的发生和发展。Objective To investigate the levels of TNF-α, IL-1, IL-6, GADA in consumed alcohol patients. Methods The levels of TNF-α, IL-1, IL-6, GADA in serum were determined in four groups： Group A （The normal body mass index and serum lipid in family history of diabetes, n = 28 ）, Group B （The high body mass index and serum lipid in family history of diabetes, n = 34 ） , Group C （ Type-2 diabetes,n =23） ,Group D （Normal control,n =21 ）. Then the levels of TNF-α, IL-1, IL-6, GADA were measured again after temperance 3 months. T-test were used to comparative each group. Results The levels of TNF-α, IL-1, IL-6, GADA in group A are higher than those of group D （ P 〈 0. 05 ） ; The levels of TNF-α, IL-1, IL-6, GADA in group B are higher than those of group D （ P 〈 0. 05 ） ; The levels of TNF-α, IL-1, IL-6, GADA in group C are significant higher than those of group D （ P 〈 0.01 ）. After temperance 3 months, the TNF-α IL-1, IL-6, GADA were decreased in high risk for diabetes consumed alcohol patients （P 〈 0. 05）. Conclusion Alcohol may induce and/or enhance insulin resistance, pancreatic islet β-cell injury when the high risk for diabetes patients consumed alcohol, and then it will induce growth and development of glucose metabolic disorder.

关 键 词：乙醇 肿瘤坏死因子-Α 白介素-1 白介素-6 谷氡酸脱羧酶抗体 

分 类 号：R446[医药卫生—诊断学]