单剂量阿托伐他汀对兔急性心肌梗死再灌注后白介素-6及无复流的影响  

Effects of One-dose Atorvastatin on Interleukin-6 and Myocardial No-reflow in Rabbit Models with Acute Myocardial Infarction and Reperfusion

作　　者：赵希军[1] 刘现亮[1] 何国祥[2] 

机构地区：[1]滨州医学院附属医院心内科,山东省滨州市256603 [2]第三军医大学西南医院心内科

出　　处：《中国全科医学》2008年第17期1541-1543,共3页Chinese General Practice

摘　　要：目的探讨单剂量阿托伐他汀对兔急性心肌梗死(AMI)再灌注后白介素-6(IL-6)水平和无复流的影响。方法将新西兰大白兔24只随机分成对照组8只、治疗组8只和假手术组8只,治疗组在造模前12h给予阿托伐他汀10mg/kg。冠状动脉结扎1h后再松解2h建立AMI再灌注模型,对3组的IL-6水平、结扎区心肌范围(LA)、无复流心肌范围(ANR)等进行比较。结果处理效应与时间效应的交互作用有统计学意义(F=25.10,P<0.01),处理主效应有统计学意义(F=15.96,P<0.01),时间主效应有统计学意义(F=98.84,P<0.01),两两比较表明各时间点的血清IL-6水平随着时间不断增高,3个时间点的血清IL-6水平呈线性趋势变化(F=164.23,P<0.01);治疗组与对照组的LA间差异无统计学意义(P>0.05),ANR间差异有统计学意义(P<0.01)。结论单剂量阿托伐他汀预治疗可有效降低血清IL-6水平,减轻AMI后再灌注时的无复流,其机制可能是通过抗炎作用实现的。Objective To evaluate the effects of one - dose atorvastatin on interleukin - 6 （ IL - 6） and myocardial no - reflow in rabbit models with acute myocardial infarction （AMI） and reperfusion. Methods Twenty - four rabbits were randomly divided into 3 groups t control group, trial group and sham - operated group. Animals in the trial group were given atorvastatin （ 10 mg/kg） before model establishment. The AMI reperfusion models were set up by 1 hour coronary ligation followed by 2 hours release. The levels of serum IL -6, myocardium area in the ligation region （LA） and the area of no -reflow myocardium （ANF） in each group were observed and compared. Results The interaction between the treatment effect and the time effect showed a statistic significance （F =25.10, P 〈0. 01 ）, the major treatment effect showed a statistic significance （F = 15.96, P 〈0. 01 ）, and the major time effect showed a statistic significance （ F = 98. 84, P 〈 0. 01 ）. The comparison between each two time points showed that the level of serum IL - 6 increased along with time change, and the level of serum IL - 6 presented a liner trend of change （ F = 164. 23, P 〈0. 01 ）. There was no significant difference in LA between the trial group and the control group （ P 〉 0. 05 ）, however there a significant difference in ANR （ P 〈 0. 01 ）. Conclusion One - dose atorvastatin can effectively reduce the level of serum IL - 6, lessen myocardial no - reflow in AMI and reperfusion. The possible mechanism may be through anti - inflammation.

关 键 词：急性心肌梗死 再灌注 无复流现象 白介素-6 阿托伐他汀 

分 类 号：R541.4[医药卫生—心血管疾病]