胰岛素样生长因子-1与冠状动脉斑块形态的关系  

Relationship between Insulin-like Growth Factor-1 and Morphology of Coronary Atherosclerotic Plaque

作　　者：刘志远[1] 张金盈[2] 李纲[1] 

机构地区：[1]河南省南阳市中心医院心内科,473009 [2]郑州大学第一附属医院心内科

出　　处：《中国全科医学》2008年第18期1628-1629,共2页Chinese General Practice

基　　金：河南省自然科学基金资助项目(0511041900)

摘　　要：目的探讨冠心病(CHD)患者胰岛素样生长因子-1(IGF-1)与冠状动脉斑块形态的关系。方法采用ELISA法测定42例CHD患者和16例对照者的IGF-1水平并分析其与冠状动脉斑块形态的关系。结果急性心肌梗死(AMI)组、不稳定型心绞痛(UAP)组患者的Ⅰ、Ⅱ、Ⅲ型斑块构成与稳定型心绞痛(SAP)组间差异均有统计学意义(P<0.01);Ⅱ型斑块组的IGF-1水平与Ⅰ型、Ⅲ型斑块组及对照组间差异均有统计学意义(P<0.01)。结论Ⅱ型斑块多发生于AMI和UAP患者中,Ⅱ型斑块者的IGF-1水平较高,斑块易损。Objective To investigate the relationship between insulin - like growth factor - 1 （ IGF - 1 ） and the morphology of coronary atherosclerotic plaque. Methods IGF - 1 levels were determined by ELISA method in 42 patients with coronary heart disease （CHD） and in 16 normal subjects, and the relationship between IGF - 1 and morphology of atherosclerotic plaque was analyzed. Results The composition of type Ⅱ plaque was obviously higher in AMI and UAP groups than in SAP group （ P 〈 0. 01 ）. The mean level of serum IGF - 1 was significantly higher in type Ⅱ plaque group than in type Ⅰ , Ⅲ plaque groups （ P 〈 0. 01 ）. Conclusion IGF - 1 plays a role in the occurance and development of atheromatous plaque, probably acting as one of the biomarkers of vulnerable plaques. Type Ⅱ plaque is prone to rupture.

关 键 词：胰岛素样生长因子-1 易损斑块 冠状动脉 冠状动脉疾病 

分 类 号：R541.4[医药卫生—心血管疾病]