经皮电神经刺激术刺激正常老年人穴位的脑功能性磁共振成像研究  

Primary study of brain fMRI under transcutaneous electric nerve stimulation in normal elderly's acupoints

作　　者：汪青松[1] 徐芳[1] 袁媛[1] 周江宁[2] 

机构地区：[1]解放军第105医院神经内科,合肥230031 [2]中国科学技术大学生命科学学院神经生物学系

出　　处：《中国临床保健杂志》2008年第4期340-342,449,共4页Chinese Journal of Clinical Healthcare

基　　金：全军十一五医药卫生科研基金(06H009)

摘　　要：目的探讨经皮电神经刺激术(TENS)改善老年性痴呆(AD)患者记忆和行为的机制。方法利用功能性磁共振方法观察正常人大脑对经皮电神经刺激术(TENS)刺激穴位的反应,刺激部位为左腿的"足三里"、"涌泉"和"太冲"穴,对6名正常老年人进行了脑部功能性磁共振成像。成像过程中,每名受试者分别接受了160 Hz的TENS刺激。结果TENS刺激正常老年人左腿的"足三里"、"涌泉"和"太冲"穴,正常老年人大脑仅在刺激"太冲"穴时可见脑区激活,它们是:下丘脑、BA6区、BA7区、BA31区、BA32区、BA38区。结论TENS可能通过激活上述结构改善老年性痴呆患者的记忆和行为。Objective To investigate the mechanism of transcutaneous electric nerve stimulation （TENS） in improving memory and behavior in patients with Alzheimer＇ s Disease （AD）. Methods The responses of human brain to stimulate acupoints under TENS was observed by functional magnetic resonance imaging （fMRI）. Each subject received TENS at Acupoints of ＂zusanli yongquan taichong＂ of the left leg at the frequency of 160 Hz. Results Brain activation could be observed under TENS in Acupoint ＂tai chong＂ ,including hypothalamus, BA6, BA7, BA31, BA32, and BA 38. Conclusion TENS might play a role in improving memory and behavior in AD patients by activating these areas.

关 键 词：阿尔茨海默病 磁共振成像 经皮神经电刺激 穴位疗法 老年人 

分 类 号：R245[医药卫生—针灸推拿学]