2型糖尿病患者C反应蛋白与血管并发症的关系  

Relationship between C-reactive protein and diabetic angiopathies in type 2 diabetics

作　　者：齐晓玲[1] 徐礼五[1] 袁玲[1] 余洋[1] 王郭伟[1] 段成[1] 王江宁[1] 刘智[1] 

机构地区：[1]安徽淮南市第一人民医院内分泌肾病科,232007

出　　处：《中国临床保健杂志》2008年第4期390-391,共2页Chinese Journal of Clinical Healthcare

摘　　要：目的探讨2型糖尿病患者C反应蛋白与血管并发症的关系及影响因素。方法140例2型糖尿病患者根据并发症发生情况分为无血管并发症组、糖尿病微血管并发症组、糖尿病大血管并发症组、糖尿病大血管并发症合并糖尿病微血管并发症组,分别检测各组血清C反应蛋白(CRP)、空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血尿酸(UA)以及体质量指数(BM I)、收缩压(SBP)、舒张压(DBP)等指标。结果与无血管并发症组相比,伴血管并发症各组血清CRP水平显著增加,差异有统计学意义。多元线性回归分析显示,体重指数(r=0.282,P=0.001)、胆固醇(r=0.159,P=0.034)、低密度脂蛋白(r=0.151,P=0.042)、收缩压(r=0.172,P=0.024)、血尿酸(r=0.181,P=0.019)与CRP密切相关。结论CRP水平与2型糖尿病血管并发症的发生、发展有关。Objective To discuss the relationship between C-reactive protein and diabetic angiopathies in type 2 diabetics and its possible factors, Methods 140 patients with T2DM, including non-angiopathy diabetic,micro-angiopathy diabetic,macro-angiopathy diabetic ,micro-and macro-angiopathy were studied. The physical examinations including the measurement of body mass index（BMI） and blood pressure （SBP and DBP）. Laboratory tests included serum c-reactive protein （ CRP）, fasting blood glucose （ FPG）, total cholesterol （ TC ）, triglycerides （ TG）, HDL- C, LDL-C and uric acid. Results The levels of serum CRP in angiopathy groups were higher than that in non-angiopathy group ,especially in the micro-and macro-angiopathy group（ P 〈 0.01 ）. Multiple linear regression analysis revealed that the levels of CRP were significantly related with the duration of diabetes, BMI, serum TC, LDL-C, SBP and UA. Conclusions There may be a correlation between serum CRP and chronic diabetic vascular complications.

关 键 词：糖尿病血管病变 C反应蛋白质 危险因素 

分 类 号：R587.23[医药卫生—内分泌]