寿胎丸对小鼠自然流产模型蜕膜组织SOCS1蛋白表达影响  

The Effect of Shou Tai Wan on the Expression of the Protein-SOCS1 at the Decidua Tissues of Mmice With Recurrent Spontaneous Abortion

作　　者：刘慧萍[1] 尤昭玲[1] 卢芳国[1] 何冬梅[1] 赖毛华[1] 周琼[1] 邓菁英[1] 王芳[1] 

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《中医药导报》2008年第8期6-8,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南省科技计划重点项目(2007FJ2005)资助

摘　　要：目的:探讨寿胎丸对反复自然流产模型小鼠蜕膜组织SOCS1蛋白表达的影响。方法:设立正常妊娠与自然流产模型,并将自然流产模型小鼠随机分为4组,分别为模型组、寿胎丸低剂量组、寿胎丸中剂量组、寿胎丸高剂量组,应用免疫组化法检测孕14 d各组蜕膜组织SOCS1蛋白的表达。结果:SOCS1在各组均有表达,模型组SOCS1比正常妊娠组明显升高(P<0.05),寿胎丸低、中、高剂量组SOCS1明显低于模型组(P<0.05),但与正常妊娠组差异无统计学意义(P>0.05)。结论:寿胎丸可能通过降低自然流产小鼠模型SOCS1表达,调控Th向Th2分化,以达到治疗反复自然流产的目的。Objective：To study the effect of Shou Tai Wau on the expression of the protein-SOCS1 at the decidua tissues of mice with recurrent spontaneous abortion. Methods： Build mice models with normal pregnancy and with spontaneous abortion,divid the mice with spontaneous abortion into 4 groups randomly：Model group, Shou Tai Wan low dose group, Shou Tai Wan middle dose group ,Shou Tai Wan high dose group. Detect the expressions of the protein-SOCS1 at the decidua tissues pregnanting for 14 days of each group by immunohistochemical method.Results： the protein-SOCS1 all has expressions in each group, compared with the group with normol pregnancy, the expression of the protein-SOCS1 obviously increased in model group（P〈0.05）;compared with the model group, in Shou Tai Wan low.middle and high dnse group ,the expression of the protein-SOCS1 obviously decreased（P〈 0.05）;but compared with the group with normol pregnancy,there was no obvious differenees（P〉0.05）.Conclusion： Shou Tai Wan may regulate the differentiation from Th1 to Th2 to attain the purpose of curing recurrent spontaneous abortion ,by decreasing the expression of the protein-SOCS1 on the mice models with spontaneous abortion.

关 键 词：反复自然流产 SOCS1 蛋白 寿胎丸 小鼠 

分 类 号：R285.5[医药卫生—中药学]