冠心病(心绞痛)辨证分型与血管紧张素转换酶基因多态性的相关性研究  

Study on Relationship Between Angiotensin-Converting Enzyme Gene Polymorphism and Chinese Medical Syndromes of Coronary Angina Pectoris

作　　者：赵国定[1] 周培芳[1] 蔡征宇[1] 苏瑾[1] 肖梅芳[1] 宋海萍[1] 田英敏 

机构地区：[1]上海市黄浦区中心医院,上海200002

出　　处：《上海中医药杂志》2008年第7期8-10,共3页Shanghai Journal of Traditional Chinese Medicine

摘　　要：目的探讨ACE I/D基因多态性与冠心病(心绞痛)辨证分型的关系。方法将115例冠心病心绞痛患者分为气阴两虚、阴虚阳亢、痰瘀交阻3组,检测其ACE基因型(II、DD、ID),并与47例正常对照组作对照。结果4组基因型(II、DD、ID)差异均有显著性意义(P<0.05)。与痰瘀交阻组比较,气阴两虚组与阴虚阳亢组的II基因型频率、I等位基因频率均明显较高(P<0.05),DD基因型频率、D等位基因频率则无明显差异(P>0.05);与阴虚阳亢组比较,气阴两虚组II基因型频率、I等位基因频率、DD基因型频率、D等位基因频率均无明显差异(P>0.05)。结论ACE I/D基因多态性可能与冠心病(心绞痛)发病相关,且其中II基因型可能与阴虚型相关。Objective To study the relationship between angiotensin-converting enzyme gene polymorphism and Chinese medical syndromes of stable coronary angina pectoris. Methods 115 cases of stable coronary angina pectoris were divided into three groups on syndrome differentiation： qi-yin deficiency group, yin-astbenia yang-hyperactivity group, and phlegm-blood stasis group. Forty-seven cases of healthy adult were enrolled as normal group. Angiotensin-converting enzyme genotypes （II, DD, ID） of these people were measured with polymerase chain reaction. Results The frequencies of angiotensin--converting enzyme genotypes（II, DD, ID） between the stable angina pectoris patients and healthy adults were of significant differences （P〈0.05）. The frequencies of II genotype were remarkably higher in qi-yin deficiency group and yin-asthenia yang-hyperactivity group than in phlegm-blood stasis group （P〈0.05）, but there was no remarkable difference between them, and of another two genotypes （DD, ID） among them. Conclusion There is a certain correlation between angiotensin- converting enzyme gene polymorphism （I/D） and the occurrence of stable angina pectoris in coronary heart disease. And II genotype may be correlated with yin asthenia in traditional Chinese medicine.

关 键 词：ACE I/D基因多态性 冠心病 心绞痛 辨证分型 

分 类 号：R541.4[医药卫生—心血管疾病]