补肾清利法对绝经后女性慢性肾盂肾炎患者泌尿道抵抗力的影响  

Influence of Kidney-Nourishing and Damp-Heat-Relieving Therapy in Increasing Urinary Tract Resistance in Postmenopausal Women with Chronic Pyelonephritis

作　　者：周家俊[1] 郭华伟[1] 姜梅玲[1] 任飞[1] 

机构地区：[1]上海中医药大学附属市中医医院肾内科,上海200071

出　　处：《上海中医药杂志》2008年第7期50-52,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市卫生局中医药科研基金资助项目(2004L012A)

摘　　要：目的观察补肾清利法对绝经后女性慢性肾盂肾炎(CPN)患者泌尿道抵抗力的影响,研究其减少CPN复发的机制。方法采用随机、对照的方法将60例CPN静止期,脾肾气阴亏虚、湿热留恋型绝经后女性患者分为治疗组和对照组各30例,并选择正常绝经后女性30例为正常组。治疗组和对照组分别接受补肾清利方、小剂量抗生素序贯治疗,疗程12周,观测尿分泌型免疫球蛋白A(尿SIgA)及阴道pH值、阴道上皮细胞成熟指数、阴道健康评分等指标的变化。结果CPN患者尿SIgA较正常人明显减少(P<0.01);治疗后治疗组尿SIgA及阴道pH值、阴道上皮细胞成熟指数、阴道健康评分均有明显好转,与对照组比较差异有统计学意义(P<0.01)。结论补肾清利法能提高CPN患者尿道局部抵抗力,这可能是其降低CPN复发的作用机制之一。Objective To observe the effect of the kidney-nourishing and damp-heat-relieving therapy in increasing the urinary tract resistance in postmenopausal women with chronic pyelonephritis （CPN） and investigate the action mechanism in reducing recurrence rate. Methods Sixty subjects were randomly divided into two groups of treatment group and control group, 30 cases in each group, which respectively received kidney-nourishing and damp-heat-relieving recipe and sequential therapy of small dose antibiotics （L-Ofloxaein, SMZ-TMP, Cistofuran） for 12 weeks. Another 30 healthy women were enrolled as control. The urine SIgA level, vaginal pH, vaginal epithelial cell maturation index were observed. Results Compared with healthy postmenopausal women, the urine SIgA of CPN women decreased significantly; treatment group predominantly exceeded control group in the improvement of urine SIgA level, vaginal pH, vaginal epithelial cell maturation index after treatment （P〈0.01）. Conclusion Kidney-nourishing and damp-heat-relieving therapy is effective in increasing the urinary tract resistance to reduce recurrence of CPN.

关 键 词：慢性肾盂肾炎 补肾清利法 尿道 抵抗力 黏膜免疫 

分 类 号：R277.5[医药卫生—中医学]