一解合方治疗更年期抑郁症42例临床观察  

Clinical Observation of "Yijiehe Decoction" in Treating 42 Cases of Climacteric Depression

作　　者：刘艳玲[1] 丁雨[1] 罗美玉[2] 董国娟[1] 宋卓敏[3] 

机构地区：[1]天津中医药大学,天津300193 [2]天津中医药大学第一附属医院妇科,天津300193 [3]天津中医药大学中医药研究院,天津300193

出　　处：《上海中医药杂志》2008年第7期53-54,共2页Shanghai Journal of Traditional Chinese Medicine

摘　　要：目的观察一解合方治疗更年期抑郁症的临床疗效及其作用机制。方法给42例患者服用中药一解合方4周,采用改良的更年期症状评分表Kupperman(KMI)和汉密尔顿抑郁量表(HAMD)进行治疗前后积分观察,同时检测血清E2、FSH、LH含量变化。结果治疗后患者KMI、HAMD积分明显降低(P<0.05);血清E2水平显著升高(P<0.05),FSH、LH含量显著降低(P<0.05);临床总有效率为88.1%。结论一解合方可通过有效调节更年期抑郁症患者内分泌激素水平而达到临床治疗效果。Objective To observe the clinical effects of ＂Yijiehe Decoction＂ in treating climacteric depression and its mechanisms. Methods Forty-two patients were treated with ＂Yijiehe Decoction＂.The HAMD scoring and KMI scoring, levels of serum estradiol （E2）, folliculestimulating hormone （FSH）, luteinizing hormone （LH） were determined before and after treatment. Results The total effective rate was 88.1%; after treatment, E2 increased and FSH, LH decreased significantly （P〈0.05）. Conclusion The mechanism of ＂Yijiehe Decoction＂ in treating climacteric depression may be adjusting the endocrinal hormones.

关 键 词：一解合方 更年期抑郁症 滋肾疏肝 化痰醒神 

分 类 号：R277.7[医药卫生—中医学]