静脉滴注丙种球蛋白治疗新生儿ABO溶血的疗效评价  

Evaluate the value of intravenous gamma globulin in therapied hemolytic disease of the newborn due to A and B incompatibility

作　　者：邓长秀[1] 

机构地区：[1]四川省人民医院儿科,四川成都610072

出　　处：《四川医学》2008年第8期1047-1048,共2页Sichuan Medical Journal

摘　　要：目的评价静脉滴注丙种球蛋白在治疗新生儿ABO溶血中的疗效。方法将2005年1月～2007年12月在我院住院治疗的98例新生儿ABO溶血患儿随机分为对照组和IVIG治疗组,比较两组间治疗前后的血清总胆红素水平及黄疸消退时间。结果治疗后72h,IVIG治疗组,血清总胆红素为(105.11±46.56)μmol/L、黄疸消退时间(5.16±2.22)d,对照组为(142.23±47.47)μmol/L、(9.02±2.14)d,差异有统计学意义(P<0.05)。结论静脉丙种球蛋白可有效阻断ABO溶血过程,迅速降低血清胆红素水平,缩短黄疸消退时间。Objective To evaluate the value of intravenous gamma globulin in therapied hemolytic disease of the newborn due to A and B incompatibility. Methods 98 hemolytic disease of the cases in our hospital from January 2005 to December 2007 was being observed. It was random divided into two groups： contal and IVIG trail one. Serum total bilirubin and jaundice extinctive time were compared with two groups in prior and post treatment. Results Serum total bilirubin, trial group and control group separate were （ 105.11±46.56 ） μmol/L and （ 142.23±47.47 ） μmol/L; jaundice extinctive time, trial group and control group separate were （ 5.16± 2.22 ） d and （ 9.02±2.14 ） d. 72 hour after therapy, there were significance of difference between two groups（ P 〈 0.05）. Conclusion The therapy of intravenous injection of gamma globulin may palliate hemolysis, extinctive level of serum total bilirubin and shorten jaundice extinctive time. It was an effective drug for treating hemolytic disease of newborn due to A and B incompatibility.

关 键 词：新生儿 溶血 黄疸 丙种球蛋白 

分 类 号：R722.18[医药卫生—儿科]