血凝-纤溶动态图在抗凝和溶栓药效研究中的应用Ⅱ  

Application of Fibrinolysodynamicogram in Pharmacodynamic Study of Anti coagulant and Thrombolytic Agents Ⅱ.

作　　者：李绍平[1] 季晖[1] 龚小健[1] 李耐三[1] 

机构地区：[1]中国药科大学药理学教研室

出　　处：《中国药科大学学报》1997年第5期298-300,共3页Journal of China Pharmaceutical University

摘　　要：对纤溶动态图在纤溶药效研究中应用的可行性进行了考察，结果表明：纤溶动态图测定参数中，相对凝固程度（ＲＣＥ）、平衡时间（ＢＴ）、完全溶解时间（ＣＤＴ）和最大溶解速度（ＭＤＲ）与纤溶作用密切相关，并呈明显的剂量依赖性（Ｐ＜０．０５）。提示：纤溶动态图是一简便有效的体外纤溶药效研究方法。Fibrinolysodynamicogram was introduced in the pharmacodynamic research of thrombolytic agents. The thrombolysis of three drugs was determined using fibrinolysodynamicogram. The data showed that relative clot efficiency (RCE)、balance time (BT)、complete dissolving time (CDT) and maximum dissolving rate (MDR), four parameters derived from fibrinolysodynamicogram, were dose dependent and obviously relevant to the fibrinolysis ( P <0.05 ) . The results suggested that fibrinolysodynamicogram is valuable in the pharmacodynamic study of thrombolytic agents and the screen of active compounds in Chinese traditional medicine.

关 键 词：血凝 纤溶动态图 抗凝血药 溶栓药 药效学 

分 类 号：R973.2[医药卫生—药品]