Synthesis and photo activity of phenylazonaphthalene peptide nucleic acid monomers  

作　　者：Jin Du Li Miao Chen Sheng Liu Hao Bo Zhang Zhi Lu Liu 

机构地区：[1]Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China [2]Graduate School of Chinese Academy of Sciences, Beijing 100039, PR China

出　　处：《Chinese Chemical Letters》2008年第7期807-810,共4页中国化学快报（英文版）

基　　金：the National Nature Science Foundation of China (No.20473106);the Innovation Group Project (No.50421502);973 project (No.2007CB607605)of the Chinese Ministry of Science & Technology.

摘　　要：Phenylazonaphthalene peptide nucleic acid （PNA） monomers were successfully synthesized, and their photoisomerization was examined. The new PNA monomers showed reversible trans-cis isomerization with UVand visible light irradiation, which might be the foundation of photo-regulating the hybridization between PNA containing phenylazonaphthalene unit and DNA. Simultaneously, the fluorescence of the new PNA monomers might make them especially useful as structural probes.Phenylazonaphthalene peptide nucleic acid （PNA） monomers were successfully synthesized, and their photoisomerization was examined. The new PNA monomers showed reversible trans-cis isomerization with UVand visible light irradiation, which might be the foundation of photo-regulating the hybridization between PNA containing phenylazonaphthalene unit and DNA. Simultaneously, the fluorescence of the new PNA monomers might make them especially useful as structural probes.

关 键 词：Peptide nucleic acid Phenylazonaphthalene PHOTOISOMERIZATION UV-vis absorption spectrometry Fluorescence spectrometry 

分 类 号：O629.7[理学—有机化学]