急性冠脉综合征患者外周血MMP-2、MCP-1的检测及意义  

Clinical significance of peripheral serum levels of MMP and MCP-1 in patients with acute coronary syndrome

作　　者：杨俊[1] 张菲斐[1] 杨海波[1] 祁华琪[1] 郭燕[1] 黄振文[1] 

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《山东医药》2008年第19期31-33,共3页Shandong Medical Journal

基　　金：河南省卫生厅基金资助项目(20060045)

摘　　要：目的研究基质金属蛋白酶-2(MMP-2)、单核细胞趋化蛋白-1(MCP-1)在不同类型冠心病(CHD)患者血清中的水平及其临床意义。方法急性心肌梗死(AMI)组24例、不稳定性心绞痛(UAP)组26例、稳定性心绞痛(SAP)组17例,另选同期20例冠状动脉造影(CAG)正常者为对照组。采用酶联免疫吸附法(ELISA)测定血清MMP-2、MCP-1水平。按Gensini评分标准对CAG结果进行评分。结果MMP-2及MCP-1在AMI组、UAP组均显著高于SAP组及对照组。ACS患者血清MMP-2与MCP-1水平呈正相关(r=0.446,P<0.05),MMP-2、MCP-1水平与Gensini积分无相关性(P>0.05)。结论ACS患者血清MMP-2、MCP-1水平明显增高,可作为ACS发病和冠脉病变不稳定严重程度的预测因子。Objective To investigate peripheral serum levels and value of matrix metalloproteinase-2 （MMP-2） and monocyte chemotactic protein-1 （ MCP-1 ） in different kinds of patients with coronary heart diseases （CHD）. Methods For 87 patients with coronary angiography （ CAG）, including acute myocardial infarction （ n = 24）, unstable angina pecto- ris （ n = 26）, stable angina pectoris （ n = 17） and healthy control group （ n = 20）, the serum concentrations of MMP-2 and MCP-1 from the elbow vein were determined by ELISA. The results of CAG were evaluated according to Gensini scoring system. Results The concentrations of MMP-2 and MCP-1 in AMI group and UAP group were significantly higher than those in SAP and control group. The concentrations of MMP-2 was positively correlated with MCP-1 significantly in ACS groups （r =0. 446,P 〈 0.05）, but there was no correlation between MMP-2, MCP-1 and Gensini scores in ACS group. Conclusion The concentrations of MMP-2 and MCP-1 were sigrdficanfly increased in patients with acute coronary syndrome （ ACS）, which may be important in prediction of the severity of vulnerable plaques and ACS.

关 键 词：急性冠脉综合征 单核细胞趋化蛋白.1 明胶酶A 

分 类 号：R541.4[医药卫生—心血管疾病]