HLA-DRB1基因多态性与扩张型心肌病的相关分析  

Correlation analysis of HLA-DRB1 gene polymorphism and dilated cardiomyopathy

作　　者：王珏[1] 刘军莉[2] 赵敬杰[2] 

机构地区：[1]山东大学威海分校海洋学院,山东威海264209 [2]山东大学第二医院临床分子实验室

出　　处：《山东医药》2008年第22期18-19,共2页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30371302)

摘　　要：目的探讨扩张型心肌病(IDC)与人类白细胞抗原(HLA)-DRB1基因多态性的关系。方法用聚合酶链反应—序列特异性引物方法检测301例IDC患者(IDC组)与436例正常人(对照组)的HLA-DRB1等位基因分布情况。结果IDC组HLA-DRB1*11、HLA-DRB1*12、HLA-DRB1*14的基因频率明显高于对照组(RR=2.91、4.02、3.78,P<0.05);IDC组同时携带HLA-DRB1*12、DRB1*14基因型的阳性率亦显著高于对照组(RR=6.24,P<0.01)。结论HLA-DRB1*11、DRB1*12、DRB1*14与IDC有明显相关性。Objective To investigate the association between dilated cardiomyopathy and polymorphism of human leu-cocyte antigen（ HLA）-DRB1. Methods The HLA-DRB1 allele distribution statuses of 301 patients with dilated cardiomyopathy and 436 healthy subjects were detected by polymerase chain reactionsequence specific primer （PCR-SSP） method. Results Gene frequency of HLA-DRB1 ＊ 11 ,DRB1 ＊ 12,DRB1 ＊ 14 alleles in IDC were significantly higher than that in control group（RR =2.91,4.02,3.78 ,P 〈0.05）. The gene frequency of HLA-DRB1 ＊ 12,DRB1 ＊ 14 alleles in IDC group was higher than those in control group （RR = 6.24, P 〈 0.01 ）. Conclusions HLA-DRB1＊11 ,DRB1＊12,DRB1＊ 14 alleles are closely correlated with IDC.

关 键 词：心肌病 人类白细胞抗原-DRB1 聚合酶链反应 

分 类 号：R542.2[医药卫生—心血管疾病]