ICAM-1在妊娠早期和流产大鼠子宫中的表达和意义  

Expression of ICAM-1 in the Uteri of Early Pregnant and Abortive Rats

作　　者：杨永倩[1] 范光丽[1] 张艳[1] 乔海莲[1] 安超翔[1] 

机构地区：[1]西北农林科技大学动物医学院,杨凌712100

出　　处：《上海交通大学学报（农业科学版）》2008年第4期277-281,共5页Journal of Shanghai Jiaotong University(Agricultural Science)

基　　金：国家自然科学基金资助项目(39670550);西北农林科技大学研究生科技创新基金(05ych020)

摘　　要：采用免疫组织化学 SP 法检测了妊娠早期和流产大鼠子宫中 ICAM-1的分布与表达。发现 ICAM-1在各组大鼠子宫腔上皮、腺上皮、子宫基质或蜕膜、子宫肌层及部分血管内皮上均有表达。妊娠早期大鼠子宫基质、肌层和蜕膜细胞中 ICAM-1的表达比发情期增加,且植入期和植入后期增加极显著(P<0.01),植入期较植入前期在以上部位中增加极显著(P<0.01),达到最高峰;植入后期肌层中 ICAM-1的表达较植入期显著降低(P<0.01)。流产大鼠蜕膜中 ICAM-1的表达显著降低(P<0.01),但子宫含胎儿部分蜕膜上皮细胞中 ICAM-1的表达较强。结果表明 ICAM-1主要在植入期发挥作用,其在妊娠早期的异常表达可能与流产有关。Immunohistochemical SP method was used to investigate the distribution of ICAM-1 in the uteri of early pregnant and abortive rats. ICAM-1 protein could be detected in all rats＇ uterine endometrial or deeidual luminalepithelium, glandular epithelium, stroma or decidua, myometrium and part vascular endothelium. The early pregnant groups showed increasing ICAM-1 expression in the stroma, myometrium and decidua. A significant increase was detected in the peri-implantation and post-implantation groups（P〈 0.01）, and the strongest staining happened in the peri-implantation period, which showed significant increase than in the pre-implantation period （P〈0.01）. ICAM-1 positive production in the myometrium of the post-implantation rats was detected to be significantly lower than that in the peri-implantation ones. The abortive rats showed distinct depression of ICAM-1 in the decidua（P〈0.01）but notable intensity in the Uterine （with fetus） epithelium cells compared with the normal group. It can be concluded that ICAM-1 contributes mainly in the peri-implantation period. And its abnormal expression in early pregnancy might hear relation with abortion.

关 键 词：ICAM-1 妊娠早期 子宫 流产 

分 类 号：S865.12[农业科学—野生动物驯养]