无精子症患者精浆果糖测定的临床价值研究  

Study on clinical value of the detection of fructose in seminal plasma in azoospermia patients

作　　者：金伟[1] 高健刚[1] 李宏军[1] 李汉忠[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院泌尿外科,北京100730

出　　处：《生殖医学杂志》2008年第4期269-271,共3页Journal of Reproductive Medicine

摘　　要：目的探讨不同病因无精子症患者精浆果糖检测对病因诊断的临床价值。方法对100例无精子症患者进行精浆果糖的定性和定量分析，检测其血清中的总睾酮（TT）；收集患者相关的临床资料如病理诊断及治疗结果。结果100例无精子症患者果糖定性在正常范围者83例，低于正常范围者17例。定量检查，精浆果糖定性阳性患者的果糖含量波动于6.7-474.1μmol/L，平均（81.1±51.6）μmol/L；精浆果糖定性阴性患者的果糖含量波动于0-8.3μmol/L，平均（2.85±2.63）μmol/L。果糖定量检测低于正常者20例，正常范围80例；其中定性测定结果低于正常范围的患者全部包含在定量测定阴性结果中。精浆果糖定量在正常范围的80例患者TT为（14.5±4.6）nmol/L，20例精浆果糖定量低下患者为（14.2±1.6）nmol/L。果糖定量低于正常的无精子症患者血清TT与对照组比较无显著差异（P〉0.05）。结论从卫生经济学角度考虑，结合病史、查体、血清激素水平测定的基础上，对高度怀疑输精管道梗阻（尤其是输精管或精囊缺如）的无精子症患者，适用于精浆果糖定性分析，而无须行定量分析。Objective： To study the diagnostic value of detection of fructose in seminal plasma of azoospermia patients.Methods： Fructose in seminal plasma was detected qualitatively and quantitatively in 100 azoospermia patients.Serum levels of total testosterone（TT） were detected,and clinical data were collected.Results：The qualitative test showed seminal fructose positive in 83 patients,negative in 17 patients.The quantitative test results were 6.7-474.1 μmol/L（average 81.1±51.6 μmol/L） in the positive patients,0-8.3 μmol/L（average 2.85±2.63） in the negative patients.Seminal fructose was below the normal range in 20 patients,within the normal range in 80 patients.The patients whose quantitative test was negative were in the coverage of negative values of qualitative test.The levels of serum TT in the patients whose seminal fructose was qualitatively positive were 14.5±4.6 nmol/L,while those in the patients whose seminal fructose was qualitatively negative were 14.2±1.6 nmol/L.No significantly difference was found.Conclusions： The result showed that the fructose concentration of semen was significantly decreased in azoospermia patients.From the economic view,for the azoospermia patients who are highly suspicious of the existence of reproductive duct obstruction,especially for those with absence of deferent duct or seminal vesicle,qualitative test of seminal fructose is enough,in combination with history,body examination,and detection of reproductive hormone.

关 键 词：无精子症 精液 果糖 睾酮 

分 类 号：R698.2[医药卫生—泌尿科学]