Study on the inclusion interaction of methylated-β-cyclodextrins with albendazole by spectrofluorimetry and its application  

作　　者：Guo Yan Zhao Hao Wu Sheng Li Dong Li Ming Du 

机构地区：[1]Analytical and Testing Center, Shanxi Normal University, Linfen 041004, China

出　　处：《Chinese Chemical Letters》2008年第8期951-954,共4页中国化学快报（英文版）

基　　金：the Natural Science Foundation of Shanxi(No.2007011027)

摘　　要：The inclusion interaction between three types of methylated-β-cyclodextrins （Me-β-CDs） and albendazole （ABZ） was studied by spectrofluorimetry. The result showed that Me-β-CDs reacted with ABZ to form an inclusion complex, 1： 1 stoichiometry for Me- β-CDs-ABZ complex was established and its association constant have been determined from fluorescence data by Benesi- Hildebrand＇s method （double reciprocal plots）. It was noted that 2,6-DM-β-CD exhibited stronger binding ability than other Me-β- CDs. Based on the significant enhancement of fluorescence intensity of inclusion complex, a simple and highly sensitive fluorimetric method is proposed for the determination of ABZ in the presence of 2,6-DM-β-CD. The proposed method was successfully applied to the determination of ABZ in tablets and human urine.The inclusion interaction between three types of methylated-β-cyclodextrins （Me-β-CDs） and albendazole （ABZ） was studied by spectrofluorimetry. The result showed that Me-β-CDs reacted with ABZ to form an inclusion complex, 1： 1 stoichiometry for Me- β-CDs-ABZ complex was established and its association constant have been determined from fluorescence data by Benesi- Hildebrand＇s method （double reciprocal plots）. It was noted that 2,6-DM-β-CD exhibited stronger binding ability than other Me-β- CDs. Based on the significant enhancement of fluorescence intensity of inclusion complex, a simple and highly sensitive fluorimetric method is proposed for the determination of ABZ in the presence of 2,6-DM-β-CD. The proposed method was successfully applied to the determination of ABZ in tablets and human urine.

关 键 词：Methylated-β-cyclodextrins ALBENDAZOLE SPECTROFLUORIMETRY 

分 类 号：O62[理学—有机化学]