血浆内皮素、NO和超声观察健康老年人血管内皮功能的变化  

Ultrasonicvisualization and ET-I and NO contrastly observe vascular endothelium function in healthy elderly

作　　者：李施勇[1] 许开宁 黄进弟 符永健[1] 

机构地区：[1]海南省安宁医院,海南海口571100

出　　处：《中国热带医学》2008年第9期1529-1530,共2页China Tropical Medicine

摘　　要：目的应用血浆内皮素、NO和超声观察健康老年血管内皮功能的变化。方法观察40例健康老年人(观察组)和32例健康青年人(对照组)血浆内皮素(ET-I)、NO水平,并用彩色多普勒超声检测二组肱动脉血流介导的血管内皮依赖性舒张功能(EDD)、硝酸甘油介导的非内皮依赖性舒张功能(EID)。比较观察组和对照组ET-I、NO和EDD的差异,并对ET-1、NO和EDD进行相关性比较。结果观察组血浆ET-I水平明显高于对照组(P<0.01),血浆NO水平明显低于对照组(P<0.01),EDD明显低于对照组(P<0.01);观察组EID与对照组比较没有差异。EDD与ET-I呈负相关,与NO呈正相关,ET-I与NO呈负相关(r=-0.5356、0.6829、-0.5828,P均<0.01)。结论健康老年人血管内皮功能下降,血浆内皮素、NO和超声都可靠地反映健康老年人血管内皮功能的变化。Objective To contrastly observe the variety of vascular endothelium function in Healthy elderly applying ultrasonic imaging method and ET - I and nitric oxide. Methods To observe the level of plasma ET - I and nitric oxide in forty healthy elderly and thirty - two healthy young people and applyultrasound to detect brachial artery endothelial dependental diastolic function（EDD） and endothelial independeutal diastolic function（EID）. Compare two groups＇ s varieties of ET- I and nitric oxide and EDD. Relativital comparison was carried out between ET - I and NO and EDD. Results The level of ET - I in healthy elderly is obviously higher than that of in healthy young people （P 〈 0.01 ） and the level of NO in healthy elderly is ob- viously lower than that of in healthy young people （P 〈 0.01 ） and EDD in healthy elderly is obviously lower than that of in healthy young people （P 〈 0.01）. The variation of ET -I is negative relativity with that of EDD and The variation of NO is positive relativity with that of EDD and the variation of ET -I is negative relativity with that of NO （r = -0. 5356 、0.6829, -0. 5828, P 〈 0.01 ）. Conclusion Vascular endothelium function in healthy elderly can be reliably disclose the vascular endothelium function in healthy elderly by using ultrasound and determination of levels of ET - 1 and NO.

关 键 词：老年人 超声显像法 内皮素 NO 

分 类 号：R331.32[医药卫生—人体生理学]