辛开苦降法对功能性消化不良大鼠胃壁肌电活动和自主神经功能的影响  

Effect of Xinkai Kujiang method on gastric myoelectrical activity and autonomic nerve function of functional dyspepsia (FD) rat

作　　者：魏玮 郝建军[2] 田俊[3] 

机构地区：[1]北京宣武中医院,北京100050 [2]武汉市中西医结合医院,武汉430022 [3]华中科技大学同济医学院,武汉430022

出　　处：《中华中医药杂志》2008年第9期837-839,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局资助(No.04-05JP11);首都医学发展基金资助项目(No.2005-SF-I-013)

摘　　要：目的:通过研究功能性消化不良(functional dyspepsia,FD)大鼠胃壁肌电活动和自主神经功能的影响,揭示辛开苦降法的整体调节机制。方法:以FD大鼠为实验对象,观察辛开苦降法对FD大鼠主频率、主功率、慢波偶连百分比的影响,评价该法对胃肠运动的影响。同时观察辛开苦降法对FD大鼠心率变异性(HRV)的影响,评价该法对自主神经功能的影响,并揭示辛开苦降法治疗FD的整体调节机制。结果:治疗前后比,模型组有变化趋势,但无统计学意义(P>0.05),胃康宁组差异非常显著(P<0.01)。本实验造模成功,模型组在观察期内有自愈倾向,胃康宁可以改善大鼠主频率、主功率、慢波偶连百分比、连续R-R间期标准差(SDNN)、高频率(HF)、低频率(LF)及LF/HF。结论:辛开苦降法对功能性消化不良大鼠的治疗作用是通过调节胃壁肌电活动和自主神经功能实现的。Objective： To research the effect of Xinkai Kujiang method on gastric myoelectrical activity and autonomic nerve function in functional dyspepsia （functional Thirty, FD） rat, and to reveal the overall regulatory mechanism of Xinkai Kujiang method and help for the clinical trials and treatment. Methods： FD rats being the experiment subject, we observed the effects of Xinkai Kujiang method on FD rat gastrointestinal movement, including the following index, the main frequency, power, even the percentage of slow wave duality. Meanwhile we observed the effect of Xinkai Kujiang method on FD rat heart rate variability （HRV）, evaluated the effect on autonomic nerve function, and revealed FD rats overall adjustment mechanism. Results： Before treatment, the result of model group, weikangning group and the normal control group was significantly different （P〈0.01）; After treatment, the results of weikangning group and the normal group had no significant difference （P 〉 0.05）, but that of weikangning and the model group had significant differences （P〈0.05）; the model group change trend had no significant difference （P 〉 0.05）, weikangning group change trend was significantly different （P〈0.01）. The results showed that the experimental model was successful. During the period of observation the model group had self-healing tendency. Weikangning can effectively improve the gastrointestinal movement of FD rats, including the main frequency, power, even the percentage of slow wave duality, SDNN, HF, LF and the LF / HF. Conclusion： The mechanism of Xinkai Kujiang method in treating functional dyspepsia is through adjusting the gastric myoelectrical activity and autonomic nerve function.

关 键 词：辛开苦降法 FD 胃电节律 心电图 

分 类 号：R259[医药卫生—中西医结合]