丹参水提液中丹酚酸B湿热降解动力学研究  

Kinetic Study on the Degradation of Salvianolic Acid B in Extract of Salvia miltiorrhiza Bge.

作　　者：林青[1] 黄琳[1] 肖晓丽[1] 陈薇[1] 李楚源[1] 

机构地区：[1]广州白云山和记黄埔中药有限公司现代中药研究院,广东广州510515

出　　处：《中国现代中药》2008年第8期29-31,共3页Modern Chinese Medicine

基　　金：广东省广州市科技局科技攻关计划项目(2004Z1-E5021)

摘　　要：目的:研究丹参水提液中丹酚酸B的湿热降解动力学。方法:以HPLC测定不同温度不同加热时间丹参水提液中丹酚酸B湿热降解动力学相关参数。结果:丹参水提液中丹酚酸B湿热降解符合一级动力学。结论:缩短丹参水提、浓缩、干燥时间,尽快使丹参水提液固体化可减少丹酚酸B损失。Objective： To perform a kinetic analysis and formulation of the degradation kinetics of Salvianolic Acid B in Extract of Salvia miltiorrhiza Bge.. Methods： The extract of Salvia miltiorrhiza Bge. was incubated at different temperature, and the degradation kinetics of Salvianolic Acid B was determined by HPLC at suitable time intervals during incubation. Results： The degradation kinetics of Salvianolic Acid B in Extract of Salvia miltiorrhiza Bge. could be appropriately simulated by first order kinetics equation. Conclusion： Shorten extracting, concentrating and drying can reduce the losing of Salvianolic Acid B.

关 键 词：丹参 丹酚酸B 化学动力学 稳定性 

分 类 号：R284.1[医药卫生—中药学] R282.710.5[医药卫生—中医学]