瑞芬太尼应用于老年患者的研究进展  

Remifentanil anesthesia in elderly patients

作　　者：赵丽艳[1] 谢红[1] 

机构地区：[1]苏州大学附属第二医院麻醉科,215004

出　　处：《国际麻醉学与复苏杂志》2008年第4期341-344,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：瑞芬太尼是一种新型的阿片μ受体激动剂，可迅速被广泛存在于血液和组织中非特异性酯酶水解。瑞芬太尼具有独特的药理学特性，起效迅速，超短效，清除率快且不依赖于肝肾功能，长期静脉输注不产生明显蓄积作用。因此瑞芬太尼适用于老年患者全麻诱导插管、麻醉维持及门诊麻醉，有利于术后认知功能的早期恢复。然而，对于瑞芬太尼所产生的心动过缓、低血压、呼吸抑制和肌肉僵直等副作用，应积极采取预防和补救措施。Remifentanil is a new μ-opiod receptor agonist, which is rapidly metabolized by nonspecific esterase throughout blood and tissues. Remifentanil has an unique pharmacological property with rapid onset and offset, ultra-short action, and rapid clearance independent of liver and renal function, without accumulation even with a long time or over-dose infusion. Therefore, remifentanil applies to induction and maintenance of general anesthesia and outpatient anesthesia in elderly patients, and is beneficial for early recovery of recognition function. However, prophylactic and remedy measures should be taken to prevent adverse effects of remifentanil such as bradycardia, hypotension, respiratory depression and muscle rigidity.

关 键 词：瑞芬太尼 老年患者 临床研究 补救措施 

分 类 号：R614[医药卫生—麻醉学]